Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Panx"”.
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
… the gonad-specific protein Panoramix (Panx) is recruited and induces transcriptional gene silencing (TGS) by connecting to the general chromatin silencing machinery of the cell resulting in changes of the epigenetic chromatin state, thus shutting down transcription. However, whether …
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Mechanisms of piRNA-guided co-transcriptional gene silencing
… proteins, this mechanism depends on the Panx-induced co-transcriptional silencing (PICTS) complex, which contains Panx, Nxf2 and Nxt1. PICTS operates at the interface between piRNA-guided Piwi and heterochromatin effectors. While the N-terminal region of Panx is known to deliver the …
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The Role of Maelstrom in the Drosophila piRNA Pathway
… by regulating the SUMOylation of Panoramix (Panx), which is a core component of the Panoramix-induced co-transcriptional silencing (PICTS) complex. The absence of Maelstrom leads to a reduction in Panx SUMOylation, compromising Panx’s ability to recruit chromatin-modifying proteins and …
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Expression und Lokalisation von Pannexinen und Connexinen in der äußeren Retina der Maus
… in Stäbchen nachgewiesen werden. Die Pannexine (Panx) wurden als kürzlich identifizierte, putative Gap-Junction-Proteine auf ihre Expression und Lokalisation in der äußeren Retina untersucht. Panx1-Transkripte konnten in Photorezeptoren, Horizontalzellen und Müllerzellen nachgewiesen werden. …
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
… of active transposons. I found that Panoramix (Panx), the central effector of piRNA-guided epigenetic silencing, assembles into a complex with two other proteins: Nxf2 and Nxt1. We characterised the dependencies within the complex and found that all three components are essential to initiate …