Global ETD Search
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Showing 1 to 5 of 5 for “"Pannexin 1 (PANX1)"”.
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Biochemical and Functional Analyses of PANX1 Variants
Pannexin 1 (PANX1) is a glycoprotein capable of forming large-pore single-membrane channels permeable to signaling molecules such as ATP. In this study, we interrogated different domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
It has been previously shown that pannexin 1 (Panx1) channels, well known for their role in ATP release, play a key role in myogenesis. However, its role in muscle development remains to be elucidated. Using a novel skeletal-muscle-specific Panx1 knockout (Panx1^smKO) mouse model, this thesis …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… nonsense alteration that yields a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. PANX1 1-89 forms a multimeric complex with wild-type PANX1 at the plasma membrane and augments PANX1 channel activity to promote cancer cell survival soon …
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Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
Pannexin-1 (Panx1) is a large pore ion/metabolite channel that is permeable to various molecules, ions, ATP, signaling lipids, and fluorescent dyes. To date, Panx1 has been implicated in many pathological conditions including ischemia, epilepsy, cancer, and inflammation. Ascribing a physiological …
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Characterization of the Zebrafish Panx1a Phosphorylation Profile and Interactome in the Regulation of the Channel Function and Trafficking
Pannexin-1 (Panx1) is an integral membrane protein that forms heptameric channels, involved in the communication between the intracellular and the extracellular environment. Its primary function is to passage small molecules, such as ATP, in and out of the cell, which can trigger vital cellular …