Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Pannexin"”.
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Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
Pannexin-1 (Panx1) is a large pore ion/metabolite channel that is permeable to various molecules, ions, ATP, signaling lipids, and fluorescent dyes. To date, Panx1 has been implicated in many pathological conditions including ischemia, epilepsy, cancer, and inflammation. Ascribing a physiological …
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Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice
Connexins (Cxs) and pannexins (Panxs) are protein families that form large-pore channels which exist at the plasma membrane for both intracellular and extracellular signaling. Given their potential for overlapping cellular signaling functions we proposed that mice lacking both a connexin and a …
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Connexin-32 and Connexin-43 Immunoreactivity in Rodent Taste Buds
… taste cells via specific hemichannels such as pannexin/connexin hemichannels (Huang et al., 2007; Romanov et al., 2007). We hypothesize that Type II (receptor) and possibly Type III (presynaptic) cells release ATP at sites containing pannexin/connexin hemichannels. In this study, we examine the …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… injury, particularly connexin hemichannels, pannexin channels and purinergic signaling, as well as to identify mechanisms of injury that are poorly attenuated by therapeutic hypothermia in order to find suitable additive treatments, such as Exendin-4. I showed that global cerebral ischemia …
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Biochemical and Functional Analyses of PANX1 Variants
Pannexin 1 (PANX1) is a glycoprotein capable of forming large-pore single-membrane channels permeable to signaling molecules such as ATP. In this study, we interrogated different domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… change the tissue environment in pathologies. Pannexin channels are also classically described as ATP releasing channels during injury. Therefore the role of pannexins and connexins in injury of the retina in this animal model needed further experimental evidence. Thus, the aim of this thesis …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
It has been previously shown that pannexin 1 (Panx1) channels, well known for their role in ATP release, play a key role in myogenesis. However, its role in muscle development remains to be elucidated. Using a novel skeletal-muscle-specific Panx1 knockout (Panx1^smKO) mouse model, this thesis …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… nonsense alteration that yields a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. PANX1 1-89 forms a multimeric complex with wild-type PANX1 at the plasma membrane and augments PANX1 channel activity to promote cancer cell survival soon …
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Characterization of the Zebrafish Panx1a Phosphorylation Profile and Interactome in the Regulation of the Channel Function and Trafficking
Pannexin-1 (Panx1) is an integral membrane protein that forms heptameric channels, involved in the communication between the intracellular and the extracellular environment. Its primary function is to passage small molecules, such as ATP, in and out of the cell, which can trigger vital cellular …
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ADP regulation of insulin secretion and beta-cell apoptosis
… blocker nifedipine, VRAC-channel inhibitor NPPB, pannexin-1 blocker carbenoxolone, or silencing of MDR1 all resulted in a substantial decrease in high glucose/palmitate induced ATP release. Furthermore, high glucose and palmitate inhibited cAMP production, reduced cell proliferation in MIN6c4 and …
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
… and that the change in ATP is modulated by Pannexin-1 channel.<br/>My findings identify MASP-2 as an early step in the pathogenesis of complement-mediated mouse kidney IRI and support its identity as a therapeutic target. Furthermore, as both monocytes and Th-17 cells have been previously …
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Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease
… without blocking gap junctions or Cx40/pannexin-1 hemichannels. As exemplified by surface plasmon resonance, the selective effect on hemichannels is due to direct binding of Gap19 to the end of CT thereby preventing intramolecular CT-CL interactions which are essential for Cx43 …
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Purinergic Receptors in the Circumvallate Papillae of Rats
<p>P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition …