Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Paneth cells"”.
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The daily rhythm of Paneth cells in <i>Mus musculus </i>
<p>Location and Morphology of Paneth Cells</p> <p>Paneth cells (Figs. 1 and 15) are conspicuous cells found at the base of the intestinal crypts, throughout the length of the small intestine, in mammals. They were first discovered by Schwalbe (1872) and extensively described by Paneth (1888). These …
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Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
… colonize the gut. Key for this balance are the Paneth cells, highly specialized secretory epithelial cells in the intestinal crypts which secrete anti-microbial peptides to regulate the microbiota. Breakdown of the symbiotic host-microbe relationship, possibly due to Paneth cell dysfunction, …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
… potential for adenomas originating from non-stem cells. I hypothesise that the stem cell supporting Paneth cells act as an intrinsic organising centre for the intestinal epithelia, thereby providing a barrier for tumorigenesis. I utilise intestinal tissue and generate various genetically modified …
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The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… conditional deletion from intestinal epithelial cells (SNX27ΔIEC), Paneth cells (SNX27ΔPC), and myeloid cells (SNX27ΔLyz) to investigate the tissue-specific roles of SNX27 in intestinal physiology. We then challenged these mice with DSS-induced colitis and AOM/DSS-induced CRC to study the …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… peptide is produced and secreted by intestinal Paneth cells as a part of innate immune response to invading microbes. Instead of killing microbes, HD6 self-assembles into higher-order oligomers to entrap and prevent microbes from invading into the host cells. This activity of HD6 is unusual …
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… formation of secretory granules in goblet and Paneth cells of the intestinal epithelium. These studies reveal non-redundant molecules required for the return of normal physiologic balance within the intestine after DSS insult.
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… gut epithelial surfaces. Mucosal epithelial cells produce a variety of secreted antimicrobial proteins that help to prevent bacterial attachment and encroachment at epithelial surfaces. Among these, Paneth cells are specialized small intestinal epithelial cells that have been shown to produce …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
Chemotherapy and radiotherapy target neoplastic cells. However, they also adversely affect progenitor cells throughout the healthy alimentary tract, resulting in severe ulceration and pain. This affects around 500,000 patients annually. The aims of the present research were to identify the main …