Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"Pandemic influenza"”.
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International Externalities in Pandemic Influenza Mitigation
A serious influenza pandemic could be devastating for the world. Ideally, such a pandemic could be contained, but this may be infeasible. One promising method for pandemic mitigation is to treat infectious individuals with antiviral pharmaceuticals. While most of the benefits from treatment accrue …
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Market incentives for pandemic influenza vaccines
… plus individuals could perish if a virulent influenza pandemic were to occur. In wake of the 2009-10 H1N1 pandemic and in an era of economic austerity, however, industry lacks clear incentives to invest in vaccines for other high-risk strains. The cyclic nature of pandemics also means we can …
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Modelling pandemic influenza progression using Spatiotemporal Epidemiological Modeller (STEM)
The purpose of this project is to incorporate a Poisson disease model into the Spatiotemporal Epidemiological Modeler (STEM) and visualize the disease spread on Google Earth. It is done through developing a Poisson disease model plug-in using the Eclipse Modeling Framework (EMF), a modeling …
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Modeling and responding to pandemic influenza : importance of population distributional attributes and non-pharmaceutical interventions
… reviewing prevalent approaches to the modeling pandemic influenza transmission, we present a simple distributional model that captures the most significant population attributes that alter the dynamics of the outbreak. We describe how diversities in activity, susceptibility and infectivity can …
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Modeling reduction of pandemic influenza using pharmaceutical and non pharmaceutical interventions in a heterogeneous population
In an event of a pandemic influenza outbreak such as the great "Spanish Flu" of 1918 and the more recent 2009-2010 H1N1 "Swine Flu" scare, pharmaceutical as well as non-pharmaceutical resources are limited in availability and effectiveness. In this thesis we apply OR methods to evaluate the …
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One Flu East, One Flu West, One Flu Over the Cuckoo's Nest: A Cross-Cultural Investigation of Pandemic Influenza Paradoxes in Epidemiology
… practices in Vietnam and the US revealed three pandemic influenza paradoxes: The paradox of attribution which asserts that pandemic influenza comes exclusively from Asia even though historical evidence points to the contrary; the paradox of prevention which encourages industrial methods (i.e., …
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Development of a conditionally-attenuated cytomegalovirus (CMV) vaccine vector platform, and initial investigations into use of CMV as a vaccine against pandemic influenza A virus
… development of CMV as a vaccine vector against pandemic influenza A (IA) virus infection. IA virus is a respiratory pathogen that despite the availability of vaccines continues to have an enormous impact on population health and world economy. Standard seasonal (epidemic) IA vaccines provide …
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Influenza : a study of contemporary medical politics
… the prevention and control of seasonal and pandemic influenza has grown to be one of the largest and most visible public health policies. This dissertation considers contemporary influenza policy as a case study in what I call medical politics, in which a disease that for most people is …
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Assessing Public Health Preparedness in Alberta Using a Systems-Level Approach
… West Nile Virus, and the increasing threat of a pandemic influenza outbreak have brought critical attention to the Canadian public health system and how prepared the system is to respond to various types of contemporary public health threats. The effective coordination of all agencies at …
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Narcolepsy associated with Pandemrix influenza vaccine: A systematic review and meta-analysis
… association between narcolepsy and the Pandemrix pandemic influenza vaccine. This particular association has been one of the most studied presumed vaccine adverse effects of the last decade and it has greatly affected the discussion on vaccine safety and vaccine hesitancy still to this date. …
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Reverse Zoonosis of Pandemic A(H1N1)pdm09 Influenza Viruses at the Swine/Human Interface
<p>The 2009 pandemic influenza A(H1N1)pdm09 virus emerged from the swine population. Despite frequent zoonotic events, swine influenza viruses had not become established in humans previously and little is known about host-barriers which prevent swine influenza viruses from efficiently infecting …
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"Send only your serious cases" : delivering flu to Toronto: an anthropological analysis of the 1918-19 influenza epidemic in Toronto, Ontario, Canada
This project looks at the 1918-19 pandemic influenza experience in Toronto, Ontario, Canada. Based on historical records (most notably death registries and archival material) this work strives to understand the social, biological, and environmental conditions that facilitated the spread of this …
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Contagious Discourse: Germs, Mass Media, and the Shaping of Reality
… invoke fear in many people, such as Ebola and pandemic influenza; multidrug-resistant strains of infectious diseases, such as tuberculosis; and agents of biological warfare, a concern that is now at the forefront with many Americans due to the most recent act of bioterrorism on American soil …
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Public Health Disasters: A Global Ethical Framework
… issues with the potential to rapidly acquire pandemic capacities. Using Ebola and pandemic influenza outbreaks, atypical drug-resistant tuberculosis and earthquakes as focal points, the dissertation argues that these issues are a type of global problems that will engender significant harm in …
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Estimating network structure and propagation dynamics for an infectious disease : towards effective vaccine allocation
In the event of a pandemic influenza outbreak, such as the 2009-2010 H1N1 "Swine Flu" episode, it is crucial to effectively allocate limited resources in order to minimize the casualties. Design of effective resource allocation strategies requires good understanding of the underlying contact …
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Statistical applications in the analysis of vaccine preventable diseases
… reproductive number and this was monitored for pandemic influenza using routinely collected data. Then postcode data was added to develop a spatial model for estimating the rate of spread.For vaccine-preventable diseases, the primary intervention strategy is vaccination but their effectiveness …
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Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
The critical first step in the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and …
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Antiviral Agents: 3,5-Disubstituted 1,2,4-Oxadiazole Derivatives and Novel Peptidomimetics Containing Hydroxyethyl Isostere and Imidazolidinone Structures
… activity against a variety of viruses, including influenza. The reoccurrence of seasonal and pandemic influenza makes this disease a major thread to human life and economic productivity.</p><p>This dissertation is concerned with the development of a small library of derivatives exploring possible …
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