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Showing 1 to 2 of 2 for “"Pancreatic islet beta cells"”.
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… proteins, Epac, are important regulators of pancreatic β-cell insulin secretion. However, the role of Rap1 in β-cell biology has not yet been defined. Here we established roles for Rap1 in distinct signaling events and begin to answer some of the key questions about Rap1 function in …