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Showing 1 to 6 of 6 for “"Pancreatic injury"”.
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Management of Blunt Pancreatic Injury by Applying the Principles of Damage Control Surgery: Experience at a Single Institution
… 받은 환자들의 의무기록을 후향적으로 조사하였다. 환자들의 기본적인 특성, 외상 기전, Injury Severity Score, 손상 받은 췌장 부위와 American Association for the Surgery of Trauma –Organ Injury Scale 분류에 따른 손상 정도, 동반된 장기손상, 수술방법, 합병증과 사망률 등의 치료 결과 등을 조사하였다. 조사기간 동안 개복수술에서 췌장손상이 확인된 환자는 총 23명이었다. 최종적인 수술소견을 근거해서 American Association for the …
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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is estimated to be the second deadliest cancer by 2030. Previous studies showed constitutive activation of KRAS (KRASG12D) is a key genetic driver of PDAC, accelerated by deletion of the epigenetic regulator Enhancer of Zeste Homologue 2 (EZH2). However, …
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Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
… have been shown to generate β-cells following pancreatic injury, represent a candidate for the ‘signal-receiving cell’. Ductal (CK19+) cells from mice pancreata obtained by purification of live Dolichos Biflorus Agglutinin lectin+ cells and cultured in minimal media supplemented with Untreated, …
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LINEAGE TRACING ANALYSIS OF PANCREATIC ACINAR CELL DE DIFFERENTIATION AND TRANS-DIFFERENTIATION IN VITRO AND IN VIVO IN THE ABSENCE OF MIST 1
Previous studies suggest that mature pancreatic acinar cells can trans- differentiate into duct and islet cells in vitro; however, the intrinsic factors regulating this process have not been defined. The acinar specific transcription factor MIST1 is required for acinar cell maturation and targeted …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with CP have a poor quality of life, and their treatment options are limited to supportive care and symptom palliation. …
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Acute pancreatitis, from local defense to remote organ injury
… Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). Gallstone migration into the common bile duct and …