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Showing 1 to 1 of 1 for “"Pancreatic cancer, Tumor-stellate crosstalk, Nucleotide synthesis"”.
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PROGRAMMED ADDICTION OF PANCREATIC CANCER TO NUCLEOTIDE METABOLISM BY THE TUMOR MICROENVIRONMENT
Pancreatic ductal adenocarcinoma (PDAC) is one of the fastest growing malignancy, yet PDAC cells face a harsh tumor microenvironment (TME) of poor nutrient availability. To adapt, they were shown to exploit stellate cells, the predominant stromal cells, for growth-promoting nutrients. However, …