Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 316 for “"Pancreas"”.
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Biopolymers for Bioartificial Pancreas
The concept of the bioartificial pancreas has developed substantially in the last decade, after the first successful islet transplantation in 2000. Islets are clusters of endocrine cells found in the pancreas. Amongst these cells, the insulin secreting beta cells are targeted by the immune system …
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Verification and Validation of Artificial Pancreas Systems Software
… standards. This dissertation examines artificial pancreas systems (APSs) as an example of emerging open-source DIY medical software solutions. We focus on AndroidAPS, an Android-based APS implementation primarily written in Kotlin. We address the need for testing and validating the app's safety …
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Manganese-stimulated protein phosphorylation in the rat pancreas.
… CaM PK III was partially purified from the rat pancreas using Mn²⁺-stimulated phosphorylation of pure EF-2 to assay its activity. Gel filtration chromatography indicated that the CaM-PK III had a Mᵣ of 150 kDa. Fractionation on the basis of isoelectric point, indicated that the majority of …
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Surgical Outcomes for Solid Pseudopapillary Neoplasm of Pancreas
… neoplasm (SPN) is a rare exocrine tumor of the pancreas with low malignant potential. This study was designed to evaluate surgical outcome of solid pseudopapillary neoplasm (SPN). Methodology: From Between January 1994 to November 2013, 41 patients were diagnosed with SPN of the pancreas at Ajou …
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Intraorgan lymphatics with special reference to the pancreas
… in the head, body and tail portions of the rat pancreas. Serial thick sections of perfused tissue were mounted on slides, with alternate sections left uncovered to be reembedded for electron microscopy. Inter and intralobular vessels, ultrastructurally confirmed as lymphatics by the absence of …
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STRATEGIES FOR REDUCING HYPOXIC INJURY TO THE BIOARTIFICAL PANCREAS
… in the destruction of beta cells within the pancreas. A promising treatment for Type-1 Diabetes is the restoration of lost beta cell mass through the implantation of immune-isolated microencapsulated islets (bioartificial pancreas). The goal of this approach is to restore blood glucose …
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The Development of a Vascularly Implanted Prosthetic Endocrine Pancreas
3cm and 1.5 cm implantable prosthetic units were constructed from biocompatible fabrication materials and consisted of a polyethylene shell containing a centrally positioned acrylic copolymer hollow fibre (M.W. cut-off 100K Daltons), with a 10 cm polyethylene cannula attached at either end. Hollow …
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An Analysis of Safe Anastomotic Method of Remnant Pancreas
본 연구의 목적은 췌십이지장절제술후에 잔여췌장의 문합방법에 따른 수술적 결과와 잔여췌장의 형태학적 결과 및 기능적인 결과를 비교 분석하여, 가장 안전하고 추천할 수 있는 문합방법을 알아 보고, 아직까지 우리나라에서는 잘 알려져 있지 않은 췌위장문합술의 안정성을 알리는 것이다. 2001년 1월부터 2006년 12월까지, 147건의 췌십이지장절제술이 아주대 병원에서 시행되었다. 수술의 적응증으로 췌담도계 및 십이지장의 악성종양환자가 124명이었으며, 췌담도계 양성질환 환자가 19명이었다. 수술방법으로 췌공장문합술과 췌위장 문합술을 …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
The exocrine pancreas comprises about 98% of the total pancreatic tissue. Its main function is the synthesis and secretion of digestive enzymes in order to facilitate nutrient absorption upon feeding. This function is mainly carried by acinar cells that require strict regulation of protein …
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Elucidating the Role of Cellular Architecture in the Developing Pancreas
… acquisition of β-cell fate in the developing pancreas, with the intention of recapitulating the events necessary in order to generate these cells in vitro for replacement therapies. Directed differentiation protocols have improved upon transitioning from 2D to 3D cultures, indicating that the …
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Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
… and tissue-level morphogenesis in the pancreas remain elusive despite a decade of studies. Here, I show that deletion of Rab11A and Rab11B (Rab11) in the developing pancreatic epithelium (Rab11pancDKO) disrupts both of these processes. The loss of Rab11 in the pancreas results in ~50% …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… epithelial and mesenchymal tissues. During pancreas development, mesenchyme-derived structures induce specification, growth and differentiation of pancreatic epithelial cells. For instance, notochord, endothelial cells, and pancreatic mesenchyme are essential for the development of the …
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Models and nonlinear control strategies for blood glucose regulation in artificial pancreas [Modelli e strategie di controllo non lineare per la regolazione della glicemia nel pancreas artificiale]
… e distrugge accidentalmente le cellule beta nel pancreas, limitando la capacità dell'organo di produrre insulina. Un pancreas artificiale è una tecnica che utilizza una pompa per somministrare la giusta quantità di insulina per via sottocutanea dopo aver analizzato i dati raccolti dai sensori, …
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Effect of progesterone on secretagogue-evoked secretory responses in the isolated pancreas
… and calcium (Ca 2+) transport in the isolated pancreas of both male and female rats. The pattern of distribution of progesterone receptors in both the male and female rat pancreas was also investigated for comparison. The results show that stimulation of the isolated pancreatic segments with …
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The action of magnesium upon stimulus-secretion coupling in the exocrine pancreas
… of magnesium homeostasis in the exocrine pancreas under agonist stimulation (b) that secretagogueevoked cellular processes in the exocrine pancreas are sensitive to physiological changes in Mg2+ and (c) the intracellular roles of Mg2+ in the secretagogue-evoked exocytotic processes in the …
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Anti-CD47 targeting therapy for the treatment of colon and pancreas cancers.
… SIRPα allowed for phagocytosis of colorectal and pancreas tumors by macrophages. In some models, treatment of xenotransplanted tumors in immunodeficient mice with anti-CD47 antibodies strongly reduced tumor growth. In other models, the combination of anti-CD47 and anti-EGFR antibodies regressed …
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