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Showing 1 to 7 of 7 for “"Pancratistatin"”.
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Synthesis of unnatural analogues of pancratistatin and narciclasine
… towards the synthesis of C-1 analogues of pancratistatin and A-ring heterocyclic analogues of narciclasine are discussed. Evaluation of the new analogues as cancer growth inhibitory agents is also described
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Mechanism Determination of the Effects of Pancratistatin on Model Mitochondrial Membranes
… specific cell types, such as cancer cells. Pancratistatin (PST) is an antiviral alkaloid metabolite that has demonstrated directed apoptotic action on various human cancer cell lines while having minimal/no toxic effect on normal cells. However, PST’s mechanism of action remains uncertain. …
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Chemistry of oxa- and aza-bicyclic(4.1.0)heptenes, total synthesis of (+)-pancratistatin
… by a concise enantiocontrolled synthesis of (+)-pancratistatin (9). The key step involved the S<sub>N</sub>2 opening of 7b with the aryl cyanocuprate derived from amide 217 to generate the pivotal cyclization precursor.
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Reactivity studies of arene-cis-diols in cycloadditions and potassium permanganate oxidations: synthesis of the corresponding arene-trans-diols and an approach to the synthesis of (+)-pancratistatin
… an approach to the amaryllidaceae alkaloid (+)-pancratistatin (12).
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Total synthesis enabled by nickel-catalyzed transformations: Dearomative carboamination and methylenecyclopropane annulation
… the completion of the synthesis of the 7-deoxypancratistatin and pancratistatin, we then developed a directed cupration/oxidation reaction to create a direct synthetic connection between the two natural products. Chapter 3 delineates how we improved the dearomative carboamination, ultimately …
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms