Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PanIN"”.
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The role of tissue-resident immune cells in PanIN to PDAC progression
… in PDAC. Pancreatic intraepithelial neoplasia (PanIN) are early malignant lesions that commonly give rise to PDAC. Using a combination of autochthonous mouse models, as well as orthotopic PanIN models, ILC2 are seen to expand and be activated in the pre-cancerous setting. ILC2 influenced the …
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Acceleration of The Panin Development In Mice Expressing Oncogenic K-Ras Due to A High Fat Diet
… that a high fat diet increased K-Ras activity, PanIN formation, and fibrotic stroma significantly compared to a control diet. Genetic deletion of Cox-2 prevented high fat diet induced fibrosis and PanIN formation in oncogenic K-Ras expressing mice. Additionally, long term consumption of high fat …
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Hubungan antara iklim organisasi dengan kepuasan kerja pada karyawan di Micro Banking Management PT. Bank Panin Tbk Surabaya Cendana Cabang Malang
… organisasi di Micro Banking Management PT. Bank Panin Tbk Surabaya Cendana Cabang Malang. 2) Untuk mengetahui tingkat kepuasan kerja di Micro Banking Management PT. Bank Panin Tbk Surabaya Cendana Cabang Malang. 3) Untuk membuktikan ada tidaknya hubungan iklim organisasi dengan kepuasan kerja di …
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Charakterisierung der Insulinrezeptor- / Insulin-Like-Growth-Factor 1-Rezeptor-Expression beim duktalen Adenokarzinom des Pankreas
… die pankreatischen intraepithelialen Neoplasien (PanIN). Es wurden 160 Pankreaskarzinomfälle und 35 Fälle mit PanIN aus dem Zeitraum von 1999 bis 2017 untersucht. Zur Einschätzung der Expression des IR und des IGF1R in den Pankreaskarzinomzellen und den Zellen der PanIN sowie der …
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Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
… pancreas, pancreatic intraepithelial neoplasia (PanIN) lesions, pancreatic adenocarcinomas, and chronic pancreatitis. In normal pancreatic ducts, integrin alpha6beta4 was noted only at the cell’s basal interface with the basement membrane. In pancreatic adenocarcinomas, 92% (104/113) demonstrated …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… the duct, Pancreatic Intraepithelial Neoplasia (PanIN) and Intraductal Papillary Mucinous Neoplasm (IPMN). During these premalignant stages, there is evidence of dysregulated metabolism present in these early lesions, including an increase in lactate production. The overarching goal of this …
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Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
… <em>Mist1</em> null mice are more susceptible to PanIN formation. The importance of MIST1 to these events suggests that modulating key pancreas transcription networks could ease clinical symptoms in patients diagnosed with pancreatitis and pancreatic cancer.</p>
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Involvement of The Receptor For Advanced Glycation End Products (Rage) In Progression of Pancreatic Cancer
<p>Oncogenic<strong> </strong><em>KRAS</em> is central to several cancer types including pancreatic ductal adenocarcinoma (PDAC), but has been determined to be “undruggable”. Recent studies have indicated that oncogenic <em>KRAS</em> is not constitutively active but relies on a feed-forward …