Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Pan3"”.
-
Structural and Biochemical Investigation of the Pan2-Pan3 Deadenylase Complex
… by two conserved multiprotein complexes: Pan2-Pan3 and Ccr4-Not. This thesis focuses on the in vitro characterisation of Pan2-Pan3. While Pan2-Pan3 and Ccr4-Not show poly(A) preference, it was unknown how the conserved exonucleases Pan2 and Caf1 recognise poly(A). In Chapter 2, structural and …
-
Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation
… that the two major deadenylation complexes, Pan3-Pan2 and Ccr4-Caf1, can both be enriched in P bodies. The deadenylase activity of the Ccr4-Caf1 complex is prerequisite for P body formation. Pan3, but not the deadenylase Pan2, is essential for P body formation. While the C-terminal domain of …
-
The Role of Phosphorylation In Pam2 Motif-Containing Proteins Mediated Messenger Rna Deadenylation
<p>Phosphorylation regulates many cellular processes. However, its role in mRNA deadenylation, a process to remove poly adenosines from the mature mRNA 3’ end tail, is unclear. The length of poly(A) tail determines mRNA stability and translation efficiency. Poly(A)-binding protein (PABP), which …