Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Pan-cancer analysis of whole genomes"”.
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
… many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel sequencing, where …
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Patterns of somatic genome rearrangement in human cancer
Cancer development is driven by somatic genome alterations, ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, …
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Signatures of chromosomal instability in human cancers
… instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the observation …