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Showing 1 to 20 of 104 for “"Palmitate"”.
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Baking performance of ascorbyl-6-palmitate in pup loaves
Typescript (photocopy).
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Investigations on the Effects of Palmitate on Neuronal Cells
… or different concentrations of BSA-conjugated palmitate (PA) and examined cell viability using MTT assay. Concentrations of PA at or above 200 μM in the growth media were associated with a decrease in cell viability. In order to examine whether N-acetylcysteine (NAC) or sodium phenylbutyrate …
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PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS
… 2004). In this thesis, it was found that SFAs palmitate exposure dose dependently reduced endothelial AMPK thr172 and eNOS ser1177 phosphorylation by western blot. Moreover, our study demonstrated that endothelial calpain, a calcium dependent protease associated with endothelial dysfunction, …
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The effect of iron metabolism on palmitate-induced INS-1 cell death
… METHODS 25 1. Cell Culture 25 2. Preparation of palmitate 25 3. Isolation of islets 25 4. MTT-bases viability assay 26 5. Measurement of cell death 26 6. Western blot analysis 27 7. RNA extraction and microarray analysis 27 8. Reverse transcriptase-polymerase chain reaction and quantitative PCR …
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The Mechanism of Palmitate Decreased Glucose Transpoter 4 Expression in C2 Myotubes
… uptake 15 5. RT-PCR 15 6. Luciferase assay 17 7. Palmitate oxidation 17 8. Pyruvate oxidation 18 9. Pyruvate assay 18 10. Transfection 19 Ⅲ. 결과 21 A. 고농도 지방산의 지속적 노출에 의한 인슐린 저항성 및 GLUT4 양적 감소 21 1. ZDF 백서의 근육에서 GLUT4 mRNA 감소 21 2. 인슐린 저항성 및 GLUT4 양적 감소 21 3. GLUT4 promoter assay 22 4. mRNA 안정성 …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… elucidate how lipid metabolism elicits glucose/palmitate-induced beta cell cytotoxicity. When the INS-1 beta cells were exposed to 0.4 mM palmitate (PA) in the presence of 25 mM glucose (high glucose: HG) for 24 hrs, cell viability was reduced due to apoptotic death. TOFA and celurenin, …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… driving the pathogenesis of obesity and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, induces ER stress and insulin resistance in skeletal muscle. However, the interaction between ER stress, lipid metabolism and T2DM remains poorly …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
… effect of nicotinamide on high glucose/palmitate (HG/PA)―induced INS-1 beta cell death. Protective effect of NAM was due to its role as an anti-oxidant, NAD+ precursor, or inhibitor of NAD+-consuming enzyme. first, Anti-oxidant activity of NAM was investigated whether other anti-oxidant …
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Mechanism of Transfer of 1-Carbon-14-Palmitate From the Abomasum of the Cow to Milk Fat
Made available in DSpace on 2014-12-12T00:36:24Z (GMT). No. of bitstreams: 1 7212429.pdf: 2810845 bytes, checksum: 2bdd0b4a7ca359b5b7a9fb34fa6a9d4c (MD5) Previous issue date: 1971
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Nutraceutical modulation of lipotoxicity and the development of a tool to monitor palmitate induced sub-cellular dysfunction.
… and the development of a tool to monitor palmitate induced sub-cellular dysfunction. - by Dean Frederick Ashley. Over 64.3% of the UK are currently overweight or obese according to the NHS survey, a number that has continued to increase throughout the beginning of the 21st century. …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
… 17 Ⅲ. 결과 19 A. INS-1 베타세포에서 고농도 포도당과 palmitate에 의한 세포사 19 1. HG/PA에 의한 INS-1 베타세포 사멸 19 2. HG/PA에 의한 insulin signals의 신호 확인 20 3. HG/PA 에 의한 inflammaion 과 stress 신호 확인 20 B. stress 그리고 inflammaion 신호에서의 INS-1 베타세포 사멸 작용기전 확인 24 1. HG/PA 에 의한 INS-1 베타세포 사멸 시 스트레스 신호의 영향 24 2. IKK 저해로 인한 …
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Development and Characterization of Fluocinolone Acetonide Loaded Nanosized Lipid Carriers for Ocular Delivery via Subconjunctival Route: Synergistic Effect of Vitamin a Palmitate
… The FA-NLCs were developed by using vitamin A palmitate as one of the lipid components, to get an additional advantage in dry eye reduction which is caused by vitamin A deficiency. FA-NLCs were evaluated for physicochemical characteristics (size, polydispersity index and charge), release and …
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Inhibition of Free fatty acid-Induced Insulin Resistance by Rosemary Extract: Investigation of the Mechanisms Involved
… involved. Exposure of L6 myotubes with the FFA palmitate significantly reduced the insulin-stimulated glucose uptake. Most importantly, the insulin-stimulated glucose uptake was restored in the presence of RE and its polyphenols CA, RA and COH. Furthermore, treatment with palmitate increased …
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An in vitro study of the effects of free fatty acids on insulin mediated glucose uptake and metabolism by myocytes and fibroblast derived adipocytes
… acids (FFAs), particulary saturated FFAs such as palmitate, are associated with insulin resistance in muscle and adipose tissue. Monounsaturated FFAs, such as oleate and essential FFAs such as omega 3 and omega 6 are claimed to be beneficial and to improve insulin sensitivity. Aim This study aims …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… show that both the acute stimulatory action of palmitate on IP3-generation, increased [Ca2+]i and insulin release as well as the long-term effects of palmitate on the activation of MAPKs (SAPK/JNK and p38), iNOS expression and caspase-3 activity is mediated via activation of GPR40. A modulated …
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Dry Period Nutrition and Hepatic Metabolism of Fatty Acids and Glucose in Transition Dairy Cows
… the effects of far-off and close-up diets on palmitate metabolism in vitro. During the far-off period, d -60 to -25, cows received a low energy control diet fed ad libitum (100NRC) to meet National Research Council (2001) nutrient requirements, a moderate-energy diet fed ad libitum to exceed …
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… is uncovered. It is reported that prolonged palmitate exposure at high glucose attenuates glucose-stimulated mitochondrial respiration which is coupled to ADP phosphorylation. These mitochondrial defects coincide with an increased level of mitochondrial reactive oxygen species (ROS), impaired …
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The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster
Salley in 1954, (122) was the first worker to use the hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that …
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Effect of early grain feeding of steers on postabsorptive capacity to utilize acetate and glucose
… feeding on acetate and glucose turnover rates, palmitate synthesis, and on acetate and glucose preference by subcutaneous, intramuscular and visceral adipose tissues in finishing steers. Sixteen Angus x Simmental steers were infused continuously with [2H3] acetate (n = 8) or [U-13C6] glucose (n …
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