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Showing 1 to 20 of 31 for “"Palladium catalysis"”.
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Palladium catalysis in the synthesis of polyaniline-related materials
The palladium-catalyzed aryl amination reaction, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. One method consists of a bidirectional chain growth from a symmetric core piece, whereas the other involves a divergent-convergent …
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Nondirected C(sp2)–H Activation of (Hetero-)Arenes Through Ligand-Enabled Palladium Catalysis
… deals with the historical development of a palladium-based catalyst system consisting of two complementary ligands, which efficiently enables C–H activation of arenes and subsequent C–H functionalization through diverse follow-up steps. The second chapter describes attempts to develop …
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Synthesis and application of sterically flexible and water-soluble phosphine ligands in palladium catalysis
… of biphasic and aqueous phase systems for palladium catalysis. My research at The University of Alabama has focused on the design and synthesis of water-soluble phosphines for application in aqueous and biphasic palladium catalysis. Our group, through collaboration with the Dixon and Rogers …
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Development of Stereoselective Hydrofunctionalization Reactions Enabled by Dual Copper (I) Hydride and Palladium Catalysis
… those which rely on dual CuH- and Pd-catalysis. Chapter one offers a synopsis on the history of CuH catalysis and the seminal discoveries in dual CuH- and Pd-catalyzed reactions. Chapter two describes the CuH-catalyzed C2-allylation of benzimidazoles. Chapter three details the …
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ANION EFFECTS IN HOMOGENOUS PALLADIUM CATALYSIS AND LUMINESCENT PROPERTIES OF COPPER(I) COMPLEXES BEARING A WEAKLY-COORDINATING ANIONIC N-HETEROCYCLIC CARBENE LIGAND
… are synthesized and paired with the same palladium cation in our first investigation. The framework of these Au(I) anions features a weakly coordinating N-heterocyclic carbene ligand that bears a borate moiety of the NHC backbone. Facile dissociation of a dimethyl sulfide ligand with metal …
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Rhodium-catalyzed Asymmetric Carbon-Carbon Bond Formation Leading to the Development of Rhodium/Palladium Multi-metal Catalysis
… alkenes and the subsequent use of rhodium and palladium catalysis in the development of domino reactions. The contents are divided into 4 chapters. Chapter 1 describes the rhodium-catalyzed asymmetric ring opening (ARO) of strained bicyclic alkenes using silyl enolates. The development of this …
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Direct arylation of 2-pyrones, coumarins, 2-pyridinones and 2-quinolones
… cross-coupling reactions proceeding via palladium catalysis, including the advances made over the past few decades in C-H bond functionalisation through direct arylation and double C-H activation is also discussed. Chapter 2 incorporates a description of two new strategies for the …
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Exploration of the use of Palladium and Nickel to Catalyze Enolate Cross-coupling and the Enantioselective Mizoroki-Heck Reaction.
<p>Palladium catalysis is a common synthetic tool utilized by organic chemists to create carbon-carbon bonds. We utilized palladium to catalyze the γ-arylation of α, β-unsaturated ketones, and esters. This work expands on palladium-catalyzed α-arylation chemistry and extends it to the vinylogous …
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Syntheses of natural bioactive 3-acyltetramic acids and derivatives
… 3 acylation conditions. Macroetherification via palladium catalysis and subsequent deprotection provided the desired macrocycles. The second target natural product of this thesis was torrubiellone D. The synthesis consisted of two major parts: the preparation of the tetramic acid core and of the …
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Palladium-catalyzed C-N cross-coupling reactions toward the synthesis of drug-like molecules
… This work will focus particularly on palladium-catalyzed cross-couplings of amine-containing compounds with aryl halides. The scope of the BrettPhos precatalyst for the cross-coupling of ortho-substituted aryl iodides with amides is studied using substrates with a variety of functional …
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Studies in palladium and rhodium catalysis: synthetic strategies for C–C bond formation
This thesis concerns studies in palladium and rhodium catalysis for carbon-carbon bond formation. Chapter 1 involves the synergistic use of tetrabutylammonium acetate (NBu4OAc) with palladium catalysis to expand on the synthesis of dibenzofurans via C-H activation. Dibenzofuran and its derivatives …
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Palladium-catalyzed C-N cross-coupling and application to the synthesis of delayed singlet emitters for OLED development
… and applying synthetic methods mediated by palladium catalysis. In Chapters 1 and 2, the palladium-catalyzed amidation and amination of five-membered heterocyclic bromides containing multiple heteroatoms are described. These methods provide efficient access to N-arylated imidazoles and …
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INVESTIGATIONS IN IRON, COPPER, AND PALLADIUM –CATALYZED C-H BOND FUNCTIONALIZATION
… of C-H bonds via iron and copper catalysis have been developed. Additionally, functionalization of sp3 C-H bonds in amino acid derivatives using auxiliary-assisted palladium-catalyzed methodology is also demonstrated. A method for iron-catalyzed alkylation of arenes and …
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Synthesis of Biologically Active Tropolones and Stereochemically Rich Compounds via Cross-Coupling Reactions
… into a whole new ligand class and asymmetric catalysis in contrast to the abundant benzenoid based privileged ligands.</p> <p>The Biscoe lab studies asymmetric C–C bond formation utilizing cross-coupling reactions such as Suzuki and Stille reactions. The Stille reaction is a chemical reaction …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… an organoboronic acid and a carbon halide under palladium catalysis. Indeed, the Nobel Prize in Chemistry was awarded to Professor Akira Suzuki, along with Professors Richard Heck and Ei-ichi Negishi, in 2010 for their important contributions in palladium-catalyzed cross-coupling chemistry. Over …
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Exploration of Transition Metal Catalyzed C−C and C−N Bond Formation to Access Synthetically Elusive Small Molecules
… revolve especially around ruthenium and palladium catalysis, accessing underexplored heterocyclic motifs. The utility of these techniques toward the synthesis of small molecules in drug discovery cannot be understated, as there are few ways to access these elusive moieties. The content is …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
… to direct C–H activation. Chapter 2 describes a palladium-catalysed Csp3–H acetoxylation directed by native secondary amines. A range of cyclic amines could be acetoxylated with excellent functional group tolerance to form the desired functionalised products. Kinetic experiments and DFT …
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Developments and applications of methods for palladium- and copper-catalyzed carbon-nitrogen bond formation
… catalyzed by late transition metals such as palladium and copper. The first part of this thesis focuses on the use of palladium catalysis for the construction of a carbon(sp²)-nitrogen bond in the context of a biphasic continuous-flow system (Chapter 1). The second part of this thesis …
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Ligand-Driven Development of Pd-Catalyzed Nondirected C–H Activation of Arenes
… exploring the potential of dual-ligand enabled palladium-catalyzed aromatic C–H activation, this dissertation presents and discusses three research projects. The first project describes the development of a nondirected C–H olefination method for the late-stage installation of clickable alkyne …
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I. Multicatalysis: Development of a BiOTf₃-catalyzed Nucleophilic Addition/Hydrofunctionalization Reaction in the Synthesis of Complex Heterocycles; . . .
… in moderate to good diastereoselectivity. The palladium-pivalate catalytic system has emerged as one of the most efficient and general catalysts for the C-H arylation of arenes and heteroarenes with haloarene donors. Despite the importance of this class of catalytic reactions, the mechanistic …
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