Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Paf1"”.
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Investigations into the Role of Paf1 Complex Proteins in Drosophila Ovaries
… the role of a chromatin modifying complex: the Paf1 complex in the maintenance and differentiation of in vivo stem cell populations that control the maintenance of Drosophila ovaries.
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Factors That Mediate Expression Of Unique Ggggcc Repeat Expansions In C9orf72-Associated Als/ftd.
… (~25% of the fly genome) and identified the PAF1 complex (PAF1C), an RNAPII-transcription factor, as a suppressor of G4C2-toxicity. Loss of PAF1C reduced RNA and peptide expression from sense-G4C2 and antisense-G2C4 transgenes in Drosophila and in yeast. Importantly, components Paf1 and Leo1 …
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Chromatin Control of the Antiviral Response to Influenza
… to bind to and disrupt the activity of the human PAF1 transcription elongation complex (PAF1C). Loss of PAF1C function leads to an impaired antiviral response and increased influenza viral replication. Genome-wide binding analyses indicate that PAF1 is inducibly recruited to anti-viral and …
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Regulation of Set1-Mediated Methylation of Dam1
… the E2-E3 ligases Rad6 and Bre1, as well as the Paf1 transcriptional elongation complex. This regulatory pathway exemplifies cross-talk <em>in trans</em> between posttranslational modifications on distinct histone molecules. Set1 has an additional substrate in the kinetochore protein Dam1, which …
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The Role of the Set1 RNA Polymerase II Interacting Motif (SRIM) in Set1 Recruitment and Histone H3K4 Methylation
… defects. The current model indicates that the Paf1 complex (RNA polymerase II associated factor I) recruits Set1C to the phosphorylated CTD of RNA polymerase II (RNAPII) and chromatin, so that Set1C can deposit histone H3K4 methylation at actively transcribed genes. Here we show that the Set1 …
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The Role of the Ubiquitin-Proteasome Pathway During Xylem Differentiation in <I>Zinnia elegans</I> Mesophyll Cells and <I>Arabidopsis thaliana</I>
… enzymes (DUBs), and an Alpha (<I>PAF1</I>) and Beta (<I>PAF1</I>) subunit of the proteasome. All targeted <I>UBC</I> families, candidate <I>UBCs</I> and DUBs, and proteasome subunits are expressed in secondary xylem and bark in this system.
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Lysine acetyltransferase Gcn5-B regulates the expression of crucial genes in Toxoplasma and its function is regulated through lysine acetylation
… subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins. The dominant-negative phenotype of ddHAGCN5b(E703G) parasites, considered with the proteomics and ChIP-chip data, indicate that GCN5b plays a central role in transcriptional and chromatin remodeling complexes. We …
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Evasion Of Innate Immunity By The Pathogen Coxiella Burnetii
… response. This effector interacts with the PAF1 Complex (PAF1C), a host factor that is highly involved in transcriptional processes and is a target of viral pathogens to counteract the antiviral response. We demonstrate that PAF1C promotes gene expression downstream of various innate immune …