Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Paediatric Malignancies"”.
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… hypotheses, we employed three cancer models from paediatric patients. To identify tumour-intrinsic mechanisms of resistance to cellular immunotherapy, we studied B-cell acute lymphoblastic leukaemia treated with CD19 CAR T-cells. To investigate the TME we utilised bulk RNA-seq from patient …
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Functional identification of molecular oncotargets associated with the resistance to ALK inhibition in neuroblastoma via genome-wide CRISPR-Cas9 screens
… Non-Small Cell Lung Cancer (NSCLC) and various paediatric malignancies. As a kinase normally only expressed during early development in the foetal brain, ALK is an ideal therapeutic target and it has proven relatively simple to target therapeutically. However, resistance to ALK-targeted therapy, …