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Showing 1 to 7 of 7 for “"Pacific Biosciences"”.
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Fast and accurate alignment of barcoded reads
… sequencing. While technologies developed by Pacific Biosciences and Oxford Nanopore accomplish this goal by producing physically longer reads, several other technologies take an alternate route by instead producing "barcoded reads", including 10x Genomics' Chromium platform and Illumina's …
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Computational Methods for Haplotype-aware De Novo Genome Assembly from Long Reads
… years, long-read sequencing technologies such as Pacific Biosciences and Oxford Nanopore Technologies, have greatly improved haplotype phasing and genome assembly because of the tremendous advantages in terms of read length. Nevertheless, the vast majority of existing long-read haplotype phasing …
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Germline and somatic mutational processes across the Tree of Life
Pacific Biosciences' circular consensus sequencing (CCS) employs a highly processive, engineered DNA polymerase to repeatedly sequence both the forward and reverse strands of a circular DNA template. By leveraging the redundancy of multiple passes and the complementarity of the strands, a consensus …
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Long read mapping at scale: Algorithms and applications
… and ultra-long read sequencing technologies by Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT). Long reads are attractive because they narrow the scale gap between sizes of genomes and sizes of sequenced reads, with the promise of avoiding assembly errors and repeat …
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Identification of Quorum Sensing Genes in Halococcus Hamelinensis SP. Nov. 100Na1
… Hcc. hamelinensis is a carboxylated AHL.</p> <p>Pacific Biosciences sequencing of genomic fosmids resulted in 36,079 bp for fosmid 17 and 34,966 bp for fosmid 18, and subsequent annotation of 30 and 18 predicted ORFs that might play a role in quorum sensing. When comparing both fosmid sequences 5 …
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Detection of zoonotic bacterial pathogens in multiple hosts using a microbiome approach and molecular characterization of Anaplasma phagocytophilum
… consensus sequencing (CCS) performed on the Pacific Biosciences platform at Washington State University. The full sample set was then also screened for the specific presence of A. phagocytophilum using a Taqman real-time PCR assay, followed by the molecular characterization and phylogenetic …
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Duplication is a prominent mechanism of recent gene birth in Caenorhabditis elegans
The high number of available reference genomes for different species and their comparison has enabled the elucidation of gene birth mechanisms that act over a long evolutionary timescale. However, the lack of several reference-quality genomes for different individuals of the same species has …