"PYRROLO[2" · 10 results · Global ETD Search

Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value

Brodrick, AndrewAston University1975

The methods available for the synthesis of pyrrolopyridines and the biological activity of the pyrrolo [2,3-b] pyridines are reviewed briefly. The reasons for the synthesis of pyrrolo [2. 3- b] pyridines from a pyrrole precursor are discussed and the possible routes from the available starting …

aston Repository record for Pyrrolo [2-3-b] Pyridines of Potential Chemotherapeutic Value (opens in a new tab)

Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors

Lin, Lu2018

… is centered on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential anticancer agents that act via microtubule inhibition or HSP90 inhibition.. Microtubule-binding agents are effective against a broad range of tumors and lymphomas and have been common components of …

duquesne Repository record for Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors (opens in a new tab)

Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer

Mohan, Rishabh2018

… selective tumor targeting with 5-substituted pyrrolo[2,3-d]pyrimidines analogs with heteroatom bridge substitution as GARFTase inhibitors. The work in this dissertation is centered on identifying structural features that are necessary for …

duquesne Repository record for Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer (opens in a new tab)

Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies

Wang, Yiqiang2018

… series of classical 5-, 6- and 7-substituted pyrrolo[2, 3-d]pyrimidines were designed and synthesized. Extensive structure modifications of the pyrrolo[2, 3-d] pyrimidine scaffold were investigated to determine selective transport via FR or/and PCFT and tumor targeted antifolates with GARFTase …

duquesne Repository record for Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies (opens in a new tab)

Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies

Li, Xinxin2019

… design and synthesis of classical 6- substituted pyrrolo[2,3-d]pyrimidines and 5-substituted pyrrolo[2,3-d]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl …

duquesne Repository record for Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies (opens in a new tab)

Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents

Karim, Mohammad2019

… tumor. Based on this premise, five 5-substituted pyrrolo[2,3-d]pyrimidines have been designed, synthesized and characterized. Among them four are novel compounds and one is a previously reported compound. The previously reported compound has never been tested for FR/PCFT-GARFTase …

duquesne Repository record for Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents (opens in a new tab)

The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions

Namjoshi, Ojas2019

Abstract withheld

duquesne Repository record for The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions (opens in a new tab)

The Synthesis of Bicyclic Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases, Microtubules or HSP90

Kurup, Sonali2019

Abstract withheld

duquesne Repository record for The Synthesis of Bicyclic Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases, Microtubules or HSP90 (opens in a new tab)

Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency

Punaha Ravindra, Manasa2019

… optimization of 5-and/or 6-substituted pyrrolo[2,3-d]pyrimidine antifolates for improved tumor-targeted activity. Molecular modeling with the help of known X-ray crystal structures of the transporters and the intracellular enzymes was used to rationalize the design of the …

duquesne Repository record for Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency (opens in a new tab)

Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents

Yang, Si2018

… Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to …

duquesne Repository record for Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents (opens in a new tab)

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