Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"PYK2"”.
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Regulation of osteoblast activity by Pyk2-targeted approaches
… understood. The proline-rich tyrosine kinase 2 (Pyk2) is important for osteoblast (OB) activity and bone formation. However, female mice lacking Pyk2 (Pyk2-KO) exhibit elevated bone volume/total volume. Previously, our laboratory found ovariectomized Pyk2-KO mice supplemented with 17β-estradiol …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… (GSK- 3beta) and proline-rich tyrosine kinase 2 (PYK2), in LTD at rat hippocampal synapses. GSK-3beta, a serine/threonine kinase implicated in the pathophysiology of schizophrenia, mood disorders, and Alzheimer's disease, is known to play a critical role in LTD. Here we report that GSK-3beta …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… cells sense changes in extracellular pH (pHo). Pyk2 is a non-receptor tyrosine kinase activated by auto-phosphorylation at Tyr402 by cell-specific stimuli, including decreased pH and is involved in the regulation of MAPK signaling pathways and transporter activity. Therefore we examined whether …
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… have identified proline-rich tyrosine kinase 2 (Pyk2) as an mGluRl/5 interacting protein, and our objective was to investigate its contribution to the downstream activation of extracellular signal-regulated kinases (ERKs) by Group I mGluRs. In HEK 293 cells, ERK1/2 phosphorylation is greater in …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
… pathway.</p><p>Proline-rich tyrosine kinase 2: Pyk2) is a non-receptor protein kinase regulated by intracellular Ca. It mediates a typical stress activated signaling pathways along with c-Src, P38 MAPK and regulates a broad range of key biological responses. By optically mapping the genetically …
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Regulation of the myogenic response and stretch-induced calcium signaling in the vascular wall: Novel insights into the role of microRNAs and protein tyrosine kinase 2
… DREAM. Using a novel small molecule inhibitor of PYK2, we demonstrated that PYK2 could distinguish between non-voltage and voltage-dependent calcium pools to initiate signal transduction in the smooth muscle of portal vein. Inhibition of PYK2 can reduce phenotype modulation and apoptosis in …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating neutrophil cells. We show that Pyk2 is specifically activated by beta2-integrin and that Pyk2 mediates …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… two adhesion-associated proteins, Src and Pyk2, which may function as “STOP” mechanosomes. Src kinase is involved in a number of signaling pathways that respond to changes in external loads on bone. An inhibition of Src causes an increase in the expression of the anabolic bone gene …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… calcium-dependent activation of PKCα-ERK and Pyk2-p38 axes, promoted chemokine expression and myofibroblast transition. Pharmacological inhibition of Pyk2 recapitulated the effects of genetic ablation, suppressing hypertrophy, fibrosis, and partially cardiac dysfunction in vivo. These findings …
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Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
… die Deaktivierung und Dephosphorylierung von Pyk2 unterbrochen. Daher scheint der Signalweg an dem Hck beteiligt ist einen wesentlichen Einfluss auf die Vermittlung von Wachstumssignalen, die über gp130 stimuliert werden, zu besitzen. Zur Zeit werden die weiteren Signale untersucht, die durch …
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… PKCepsilon downstream signaling, most likely to Pyk2, promoting the formation of polyFn surface formation. These results present a novel potential signaling pathway for therapeutical intervention in breast cancer metastasis.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… including protein tyrosine kinase 2 (PYK2) and pseudopodium-enriched atypical kinase 1 (PEAK1). Furthermore, utilization of a novel DDR1 small molecule inhibitor (7rh) abrogated collagen-induced DDR1 signaling and blunted tumor cell colony formation, migration, and enhanced sensitivity …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… synaptic activity and localization, Src and Pyk2, were shown to be phospho-activated in the cerebellar cultures at a timepoint that correlated with the increases in PSD-95 and NR2B-pY1472, implicating them in the targeting of the NMDAR to the synapse. These findings are intriguing, since …