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Showing 1 to 1 of 1 for “"PX-866"”.
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The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
… phosphatidylinositol 3-kinase (PI3K) inhibitor, PX-866, suppressed Ad-5-induced SRBEP1 expression and hypertriglyceridemia implicating the PI3K/Akt pathway in Ad-5 activation of SREBP1. Use of PX-866 led to the discovery of a third mechanism of SREBP1 regulation. In vivo studies demonstrate that …