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Showing 1 to 4 of 4 for “"PVPVA"”.
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The Influence of PVAP on the Stability of Amorphous Solid Dispersions of Itraconazole Produced using Hot Melt Extrusion Technology
… over time. Polyvinyl pyrrolidone vinyl acetate (PVPVA) was incorporated into PVAP as a carrier matrix with the aim of lowering the melt viscosity and increasing the plasticity of PVAP while maintaining its high glass transition temperature (Tg). Amorphous solid dispersions of ITZ (40% w/w) in a …
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Investigating the Variations in Molecular Mobility within Amorphous Formulations using Terahertz Spectroscopy
… Polyvinylpyrrolidone/vinyl acetate copolymer (PVPVA), used to formulate poorly water-soluble drugs, was used as the polymer for all investigations. PVPVA exhibits hygroscopic behaviour and will absorb water over time. The residual water inherently present in the PVPVA backbone is often …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
… (PVP) and poly(vinylpyrrolidone-vinyl acetate) (PVPVA) provided complementary benefits: PVP facilitated strong hydrogen bonding for enhanced chemical protection, whereas PVPVA offered lower hygroscopicity and greater resistance to humidity-induced plasticisation. These findings were extended to …
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Modeling and Prediction of Amorphous Solid Dispersion Formation Using a Molecular Descriptor
… with the probability that an ASD will form in PVPva. Since molecular descriptors are mathematical representations of properties of a molecule, it is hypothesized that they can be successfully applied to predict the formation of amorphous solid dispersions. Specifically, the molecular descriptor …