Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"PULMONARY METASTASES"”.
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A Screen For Peptides Targeting Chemoresistant Metastatic Triple-Negative Breast Cancer
… agent cisplatin exacerbates spontaneous metastases to the lung. In this project, we have aimed to develop novel compounds that specifically target chemoresistant cancer metastases. It is based on the hypothesis that metastatic cancer cells express unique cell surface receptors that can be …
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Surgical Outcomes Following Pulmonary Metastasectomy in Iceland
Introduction: Pulmonary metastases usually indicate an advanced systemic disease and are generally associated with a poor prognosis. A small, carefully selected proportion of patients with pulmonary metastases undergo surgery. Aim: To evaluate the outcomes and trends of pulmonary metastasectomies …
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A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
… the ability of breast cancer cells to form pulmonary metastases in mice. These results demonstrate that Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer.
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Wilms' tumour outcomes at Red Cross Children's Hospital 1979-2003
… was reserved for local stage III tumours and pulmonary metastases. Patients with bilateral Wilms' tumours underwent initial bilateral biopsy, neoadjuvant chemotherapy and tumourectomy. Where indicated, nephrectomy (partial or complete) involved using ice dam topical cooling and vascular …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… iNKT cells from stressed mice fail to prevent pulmonary metastases of B16 melanoma. MAIT cells also upregulate TIGIT and are incapable of mounting optimal TH1- and TH2-type responses during stress. Lastly, these inhibitory effects are not simply due to cell death since human and mouse iNKT and …
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Effects of consuming thermally abused frying oil on breast cancer metastasis
… Further histopathological analysis of the pulmonary metastases localized within the lung tissue showed enhanced outgrowth of metastasis, particularly within blood vessels among the TAFO treatment groups. These data may contribute to the reduction of diet-related environmental risk factors …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… across a variety of patients and an ex vivo pulmonary metastasis assay (new reagent) that allows real-time assessment of metastatic progression in a relevant microenvironment. Furthermore, cancer cells are believed to efficiently regulate protein translation at specific times and locations in …
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ADAMTS1 is a promoter of metastatic cell behaviour in mammary cancer cells.
… impeded the aggressive advancement and growth of pulmonary metastases. The signalling pathways and mechanistic events through which ADAMTS1 mediates its pro-metastatic effects are currently unknown. The aim of this present study is to therefore identify the causal events imposed by ADAMTS1 to …
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Complicaciones respiratorias en pacientes intervenidos por cáncer de cavidad oral, faringe y laringe en La Rioja
… with comorbidities, notably chronic obstructive pulmonary disease (COPD). Several authors have shown that the presence of COPD increases the incidence of respiratory complications. The relationship between HNC, smoking, and COPD should be studied in detail to identify actions that reduce their …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The degradation of …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… upregulation of Fas in established OS lung metastases results in tumor regression. Therefore, agents that upregulate Fas expression or activate the Fas signaling pathway may have therapeutic potential.</p> <p>Treatment of Fas<sup>-</sup> metastatic OS cell lines with 2 μM MS-275 sensitized …