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Showing 1 to 20 of 27 for “"PU.1"”.
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Identification of genes regulated by the transcription factor PU.1
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1
… Rolle in der Entwicklung myeloischer Zellen. PU.1, ein Transkriptionsfaktor aus der ETS-Familie, ist sowohl für die Entwicklung lymphatischer als auch für die Entwicklung myeloischer Zellen von Bedeutung. Der Transkriptions faktor C/EBPalpha, ein an den CCAAT-Enhancer bindendes Protein, ist …
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AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia
… of AML1-ETO on the transcriptional activity of PU.1, an important transcription factor for normal myeloid differentiation. We have demonstrated that AML1-ETO interacts with PU.1 by immunoprecipitation assay in Kasumi-1 cells having t(8;21). On mapping the region of interaction in PU.1, we found …
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… in genes encoding transcription factors. PU.1 is a transcription factor that is required for the development of nearly all white blood cell types of the immune system, including B cells, granulocytes, and monocytes. Mutation of the gene encoding PU.1, SPI1 in humans and Sfpi1 in mice, is …
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Identification and characterisation of Pu.1-driven gene regulatory complexes and networks in Acute Myeloid Leukaemia.
PU.1, an ETS-family transcription factor, is a master haematopoietic regulator required for the development and differentiation of both mature lymphoid and myeloid cells. The dysregulation of key haematopoietic transcription factors, including PU.1, is a cardinal feature of acute myeloid leukaemia …
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PU.1-ACTIVATED GENOMIC REGIONS DEFINE LOW-RISK MDS SUBSETS CHARACTERIZED BY IMMUNE DYSREGULATION AND DISEASE PROGRESSION
… progression. This subset is characterized by PU.1 genomic occupancy in regions linked to immune and inflammatory responses, increased T-cell and NK activation, and a higher frequency of SRSF2 mutations. Clinically, patients in this group exhibit greater susceptibility to infections and …
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Role of microRNA-155 in dendritic cells and macrophages: MiR-155 directly targets PU.1 and IL13Rα1
… two pro-Th<sub>2</sub> targets for miR-155: PU.1 and IL13Rα1. PU.1 is a transcription factor essential in myelopoiesis and dendritic cells (DCs) that favours a Th<sub>2</sub> profiling; moreover, PU.1 had been shown to regulate the transcription of DC-SIGN (Dendritic Cell-Specific ICAM-3 …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… and commitment to a specific Th lineage. The population of Th2 cells can be subdivided in subpopulations depending on the level of a cytokine and the subsets of cytokines they produce. Very limited information is available about the regulation of cytokine production in this array of Th2 cells. …
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Transcription factor regulation of T helper subset function
… a requirement for the transcription factor PU.1 in the development of IL-9-secreting Th9 cells. Work in this dissertation demonstrates that the Th9 subset is not stable in vitro, and that PU.1 expression decreases during long-term culture. To examine a role for PU.1 in Th9-independent …
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In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia
… radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
… of genes encoding the ETS transcription factors, PU.1 and Spi-B. Whole exome sequencing was performed on PU.1-/Spi-B null leukemias to identify additional driver mutations and showed that there were frequent mutations in ETS variant transcription factor 5 (ETV5), which included R392P, V444I, and …
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… fibroblast-like cells. The transcription factor PU.1 is important for myeloid cell development and function, but has not previously been investigated in adult human microglia. In this study PU.1 has been identified for the first time in adult human brain tissue and microglia, and demonstrated to …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a model in which NFIX collaborates with PU.1 to regulate differentiation and …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… that promote Th9 development include STATs, PU.1, BATF, and IRF4. In this study, we identify ETV5 as a factor that promotes IL-9 and IL-10 production by binding to cis-acting regulatory elements in the respective genes. At the Il9 gene, ETV5 cooperates with PU.1 in regulating gene expression. …
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Identification and Characterization of Control Elements within the Murine CD4 Gene
… and AP-1 for the 5' intronic enhancer, and PU.1, IRF-1, and GATA-1 for the 3' intronic enhancer. Among them, Elf-1 and PU.1, members of the Ets protein family, and AP-1 have been implicated in the regulation of T cell-specific gene expression. An intronic promoter is located in the 138 bp …
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RBP-J dependent and independent signalling of EBNA-2
… cellular DNA-binding proteins, such as RBP-J and PU.1, since EBNA-2 does not contain its own DNA-binding domain. In order to better characterise EBNA-2 signalling we conducted a mutational analysis of the viral LMP-1 promoter that is strongly induced by EBNA-2 in the EBV-immortalised B-cells. Our …
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C/EBPalpha downregualtes c-jun expression
… and a co-activator of the transcription factor PU.1, is important for monocytic differentiation. Here we report that C/EBPa downregulates c-jun expression to drive granulocytic differentiation. Ectopic increase of C/EBPa expression decreases c-jun mRNA level, and the human c-jun promoter …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… by the haematopoietic transcription factors PU.1 and RUNX1. Interference with their binding leads to abrogation of Irf8 expression, subsequently to disturbed cell fate decisions, demonstrating the importance of these factors for proper phagocyte cell development. Collectively, these data …
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Preferential nanoreinforcement of thermoplastic polyurethane elastomers with dispersed nano-clay
… in three thermoplastic polyurethane elastomers (TPUs) -- Elasthane 80A, HDI-PTMO PU, and PU-1-33 -- has been developed. This clay was selected because the diameter of one platelet is similar to the lateral dimension of a single hard-domain in block-polymeric TPU. WAXD, TEM, and AFM phase imaging …
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Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
… and transcription factors C/EBP-α, C/EBP-β and PU.1 was measured by real-time PCR. Plasma PR3, pro-PR3, and proportion of mPR3+neutrophils were elevated in AASV. mPR3 and CD177 were co-expressed on a subset of neutrophils both in AASV and controls. mPR3 expression was not correlated directly to …
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