Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"PTX"”.
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A Model for the PTX Properties of H2O-NaCl
In many geologic environments, fluids have compositions that are approximated by the H₂O-NaCl system. When minerals grow in the presence of such fluids, some of the solution is trapped in the growing mineral as fluid inclusions. The salinity, temperature of homogenization, and pressure of …
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Mitigating Inhomogeneity in High-Field MRI Excitations: Arbitrary Waveform Optimization and Multiphoton Parallel Transmission (MP-pTx)
… the imaging region. Parallel transmission (pTx) mitigates this issue by employing multiple high-power, independently controlled transmit elements for more precise excitation control. However, since the wavelength of the applied radio waves is shortened in tissue, the effect becomes highly …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
<p>Paclitaxel (PTX), a chemotherapeutic that alters microtubule dynamics, is known to induce nociceptive hypersensitivity and sensory neuron damage in human patients and in Drosophila larvae. We used a modified feeding protocol to establish a genetically tractable Drosophila model of PTX-induced …
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Parallel transmit pulse sequence design for ultra-high field (7T) MRI
… image homogeneity is parallel transmission (pTx). A pTx-enabled scanner has multiple independently-driven transmit channels, providing additional degrees of freedom for improved spatial and temporal control of the B+1 fields. This thesis aims to extend the methodology and applications of pTx …
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Effects of pentoxifylline on exercising skeletal muscle vascular control in rats with chronic heart failure
… TNF-[alpha] synthesis suppressor pentoxifylline (PTX) reduces plasma [TNF-[alpha]] and improves left ventricular (LV) function in CHF rats, but the effects of PTX on skeletal muscle blood flow (BF) and vascular conductance (VC) during exercise are unknown. We tested the hypothesis that PTX would …
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Slice-selective parallel transmit magnetic resonance imaging at 7T
… and contrast losses. Parallel transmission (pTx) technology, employing multiple transmit channels to dynamically control RF pulses, is a promising solution to overcome these limitations. While pTx has shown maturity in 3D neuroimaging with universal pulses, its application to 2D imaging …
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Excitation and readout Designs for high field spectroscopic imaging
… RF excitation with parallel transmission (pTx) and magnetic resonance spectroscopic imaging (MRSI). Recent work in parallel RF excitation in MRI has been demonstrated to offer dramatically improved flexibility for manipulation of magnetization preparation for imaging than is feasible with …
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Parallel radiofrequency transmission for 3 Tesla and 7 Tesla magnetic resonance imaging
… the imaging speed. Parallel RF transmission (pTx) was proposed to address both of these challenges by optimization of RF pulses transmitted from multiple independent channels simultaneously. However, both the RF pulse design and RF safety management become more complicated with pTx. In this …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… life. Among chemotherapeutic agents, paclitaxel (PTX) stands out for its broad clinical use across several cancer types, and its use is strongly associated with the development of chronic neuropathic pain, particularly in women. This pain represents a clinically significant component of CIPN, yet …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
… of the nanoparticle (NP). The selection of PTX and SEL for being loaded on α-MSH-SPION takes into consideration the anti-melanoma potency, mechanism(s) of action, physicochemical properties of each drug and their ability for embedding in the hydrophobic pocket of the NP. The synergistic …
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Multiphoton Parallel Transmit MRI for Flip Angle Mitigation Without SAR Concerns
… in a process known as parallel transmit (pTx). While these multiple high-power, high-frequency transmit channels can solve the flip angle inhomogeneity problem, they are expensive and complicate the management of electromagnetic power dissipation in the body, known as the specific …
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Magnetic resonance spectroscopic imaging using parallel transmission at 7T
… hardware at 7T, so-called parallel transmission (pTx). The B1 homogeneity of the pTx excitations improved at least by a factor of 4 (measured by the normalized spatial standard deviations) compared to conventional single channel transmit systems. The first contribution of this thesis describes the …
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NANOPARTICLE DEPOT FOR INTRAPERITONEAL CHEMOTHERAPY OF OVARIAN CANCER
… for IP chemotherapy consisted of paclitaxel (PTX) nanocrystals (PNC) and hyaluronic acid-based hydrogel (HA gel). PNC with a size of ~310 nm was produced by nonsolvent and temperature-induced crystallization. Dissolution kinetics of PNC could be determined by the light scattering method rather …
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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… adverse effects on healthy tissues. Paclitaxel (PTX) has been used as a gold standard chemotherapeutic agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. Till date, PTX has been used as the first line of treatment for metastatic breast cancer. However, being …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… </p> <p>A solid dispersion system of paclitaxel (PTX) was also developed to increase the aqueous solubility in order to overcome the side effects of its commercial products Taxol® , which was accomplished with the addition of a non-ionic surfactant, Cremophor® EL. PolyOx™ WSR N-80 (Molecular …
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Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
… were conjugated with PSMA antibody resulting in PTX-PBNM-Ab. XRD, FT-IR and the H-NMR analyses confirmed the structure of the pentablock copolymers. Chapter #5 discusses the preparation of a hydrophobic ion-paring complex (HIP complex) of doxorubicin using hydrophobic retinoic acid. The resultant …
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Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction
… on in vivo data. Parallel Transmission (pTx) improves image quality and patient safety in high-field MRI. Unlike in single-channel MR excitation, an array of multiple excitation coils is used in pTx. However, coupling between these independent coils significantly degrades the power …
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Analysis of Events with Isolated Leptons and Missing Transverse Momentum in ep Collisions at HERA
… events with high hadronic transverse momentum PTX > 25 GeV. New data of the HERA-2 period are added. The analysed data sample recorded in e+p collisions corresponds to an integrated luminosity of 220 pb-1 which is a factor of two more with respect to the HERA-1 analysis. The e-p data correspond …
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Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
… in parathyroid-intact and parathyroidectomized (PTX) rats. We demonstrated that acute hypercalcemia decreased PRA, and that this inhibition of PRA is blocked by pharmacological CaSR antagonists and by PTX. Acute supplementation of PTH did not affect the inhibition of PRA by high calcium. Acute …
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A spectroscopic study of square planar platinum (2) complexes
… relation to one another. The complexes trans-[PtX₂ (CO) (L)] (X = Cl, Br; L = aniline, pyridine N-oxide, pyridine, ammonia, imidazole and pyrazole) were prepared from their corresponding ethylene analogues. Infrared assignments, with labelling studies, are given for the complexes. The bonding …
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