Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PTPN22"”.
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
… immunization. Hematopoietic cell-specific PTPN22 encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and Pattern Recognition Receptor (PRR) signaling. A PTPN22 variant R620W (LypW) predisposes to autoimmune and infectious disease, and confers altered signaling …
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The genetic background of gestational diabetes mellitus
… protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. The …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… protein tyrosine phosphatase, non-receptor 22 (PTPN22), whether these phosphatases are activated upon LAIR-1 and its ligand interaction, and whether SHP1 plays a role in LAIR-1 signaling and T cell activation.</p> <p>I validated previous findings that suggested LAIR-1 stimulation by its natural …
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The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
… 870 MPO-AAV cases and 11,947 controls. For PTPN22 (rs6679677), a further replication cohort, previously genotyped using the Sequenom MassARRAY platform, and comprising 1,122 PR3-AAV and 347 MPO-AAV cases and 1,531 controls was included in the combined analysis. This is the largest …
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Perfil de expressão de genes relacionados a doenças autoimunes/inflamatórias em indivíduos com síndrome de down
… do sistema imunológico, como o CTLA-4 e PTPN22. O presente estudo avaliou o perfil de expressão dos genes NLRP1, NLRP3, IL-1β, CTLA-4 e PTPN22 em indivíduos com SD suscetíveis ao desenvolvimento de doenças autoimunes/inflamatórias. Além disso, avaliamos se os pacientes com SD apresentam …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA), with age at onset after 35 years and non-insulin requiring at least for 6 month after diagnosis. On the other …
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The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
… I was not able to replicate the association in PTPN22, which was reported to be a risk factor for drug-induced liver damage by Cirulli et al. – suggesting that its effect might be heterogeneous depending on the therapy. Finally, the third research chapter describes the initial analysis of the …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… phosphatase non-receptor type 2 (PTPN2) and PTPN22, and several receptor-type PTPs (RPTPs) in HD as well as SLE CD19+ B cells upon CD40L/IL-4 co-stimulation. Contrary to the general understanding of B cell hyperreactivity in autoimmune diseases, this study found peripheral and tissue resident …