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Showing 1 to 2 of 2 for “"PTPN14"”.
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… protein, the non-receptor tyrosine phosphatase PTPN14<em>,</em> is mutated or deleted in several human cancers suggesting that it may be involved in tumor development and/or progression. Additionally, the loss of the FERM domain protein Merlin is associated with tumor development and …
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Functional Characterization of Protein Tyrosine Phosphatases in Tumorigenesis through Substrate Identification
… of cellular functions of two PTPs: PTPRT and PTPN14, both of which are mutated in multiple cancer types, including colorectal cancers.</p><p>We utilized a proteomic approach to search for substrates of PTPN14 in colorectal cancer cells. We identified and validated that p130Cas is a direct …