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Showing 1 to 3 of 3 for “"PTPA"”.
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Exploring the Regulation of Mitotic PP2A-Rts1 Activity in Saccharomyces cerevisiae
… with the mammalian PP2A phosphatase activator (PTPA), PP2A gains phosphotyrosine specificity. My work indicates that Rrd1 and Rrd2 (the budding yeast homologs of PTPA) genetically interact with PP2ARts1 and the absence of these proteins cause a Swe1-dependent delay in mitosis. In parallel, …
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Small Phosphomonoesters as Probes of Protein-Tyrosine Phosphatase Active Sites
… phosphatases [DSPs]. Three PTPs, PTP-1B, Tc-PTPa, and PTP-H1, and three DSPs, Cdc-14, VHR, and IphP, were challenged in vitro with alpha-naphthyl phosphate and beta-naphthyl phosphate. Both the DSPs and PTPs readily hydrolyzed beta-naphthyl phosphate. As expected, the DSPs also hydrolyzed …
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Untersuchungen zu bioabbaubaren Genvektoren und in situ gebildeten Filmen als neue Arzneiformen für die Applikation von Gentherapeutika
… Einbau einer für tPA kodierenden Plasmid-DNA (ptPA) in den Sprühfilm führte zu einem tPA-Spiegel von 2 ng/ml über einen Zeitraum von 16 Tagen in vitro. Ferner konnte durch Kotransfektion der Plasmid-DNA mit einer siRNA gegen PAI-1 ohne Einbau in den Film eine 8,3 fache Steigerung des …