Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"PTP1B"”.
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Conserved Conformational Dynamics Control PTP1B Enzymatic Activity
… we studied Protein Tyrosine Phosphatase 1B (PTP1B), one of the most well-studied PTPs, as a model system. First, to establish a comprehensive understanding of PTP1B dynamics, we performed a full 13C methyl relaxation study of Ile, Leu and Val (ILV) residues of PTP1B. In combination with …
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Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model
… in offspring. Protein tyrosine phosphatase (PTP1B) is recruited during inflammation and its regulatory proteins are modulated in MIA. Disrupted regulation of PTP1B has been linked to mental disorders such as Rett Syndrome and anxiety. We asked if ablating neuronal PTP1B could protect from the …
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase implicated in the central control of energy homeostasis via negative regulation of leptin signaling. Mice with central nervous system (CNS)-specific PTP1B deficiency demonstrate clear metabolic improvements, …
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Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice
Metabolic syndrome describes a complex set of obesity-related disorders that enhance diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase lb (PTPlb) deletion mice (L-PTPlb-/-) suggests that hepatic PTPlb inhibition would mitigate metabolic syndrome …
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Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases
… associated with allostery. The archetypal PTP, PTP1B, has been highly validated as a therapeutic target but no allosteric inhibitors have been approved for clinical use. This is largely because our understanding of the mechanisms underlying allostery in PTP1B remains limited, despite the …
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Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
… REQUEST.] Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator in the insulin signaling cascade. A lot of research has focused on inhibiting PTP1B but with no success. Only one drug is currently in phase II clinical trials. We have developed a synthetic protocol to create a …
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Metabolic Bioactivity of Athrixia phylicoides
… The inhibitory effect of A. phylicoides on PTP1B enzyme activity was also assessed. Six-week old obese C57BLKS db/db mice were treated with A. phylicoides extract (20 and 200 mg/kg body weight) in the diet for 30 days. Body weights, fasting blood glucose levels, food and water intake were …
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Assessment of chemical markers as surrogates for efficacy and safety of Rooibos extracts
… against the protein tyrosine phosphatase 1B (PTP1B) enzyme. To investigate the possible mechanism of action of glucose uptake in C2C12 cells, protein expression studies were conducted. Multivariate statistical analysis was performed using principle component analysis (PCA), to elucidate the …
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Novel cell-penetrating peptide-based vectors for siRNA delivery
… non-specific siRNA effects. Effects on PTP1B expression were also examined with all purified proteins complexed with the optimum molar concentration of PTPN1 siRNA; none were able to exhibit PTP1B expression knockdown at the protein level. In this thesis, a comprehensive strategy for the …
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Interactive Effects of Macronutrients on Obesity and Metabolic Syndrome Development
… decrease in protein tyrosine phosphatase 1B (PTP1B) expression, suggesting partial upregulation of insulin signaling. In muscle, the glucose transporter GLUT4 and PGC-1a were induced by both low protein and fructose. Low protein also induced pyruvate dehydrogenase 4 (PDK4) in skeletal muscle, …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
… and protein-tyrosine phosphatase 1B (PTP1B) that are a therapeutic target for the treatment of diabetes and other metabolic syndromes. The fractionation of SBT531 afforded a series of bioactive alpha and beta-hydroxy acid derivatives and allowed the definition of a preliminary …
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On the role of SOCS proteins in leptin signalling
… must be under stringent control. SOCS3 and PTP1B are the best characterized mediators of leptin signalling termination. In this work we focus on the role of SOCS proteins in leptin receptor signalling. SOCS proteins are typically inhibitors of cytokine receptor signalling and consist of an …
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Design and Development of a Novel Immunological Method to Quantify target-specific cysteine redox state in a microplate
… protein tyrosine (Tyr) phosphatase (PTP) 1B<br/>(PTP1B), Src homology 2 domain-containing protein Tyr phosphatase 1 (SHP-<br/>1), cluster of differentiation 45 (CD45) and the cα subunit of protein phosphatase<br/>2A (PP2A) -specific thiol oxidation, without altering the thiol oxidation of …
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DNA catalysts as phosphatases and as phosphoserine lyases
… expressed Protein Tyrosine Phosphatase (PTP1B). Separately, efforts were directed towards the important goal of identifying sequence-selective phosphatase deoxyribozymes. Although three separate efforts were directed towards identifying sequence-selective phosphatases deoxyribozymes, we …