Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"PTMs"”.
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… of host post-translational modifications (PTMs), to attenuate inflammation. The Bengoechea laboratory has previously demonstrated that Klebsiella triggers a type I interferon (IFN) response in vivo and here it is shown Klebsiella targets ISGylation, a type I IFN-dependent PTM, in vitro. …
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Algorithms to Detect Motifs and Predict Post-Translational Modification Sites
Post-translational modifications (PTMs) are an important step in the formation of a mature protein. While much is known about some PTMs such as Phosphorylation, there are other PTMs such as Cysteine S-sulfenylation that are currently being researched and analyzed. For this project, an algorithm, …
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Development of Dendrimer-based Technologies for Phosphoproteomics and Glycoproteomics in Biomarker Discovery
The dynamics of post-translational modifications (PTMs) of proteins keeps cells adapting to the ever-changing microenvironment by regulating protein structure and function in the real-time mode. Of all PTMs, protein phosphorylation and glycosylation are undoubtedly two of the most common and …
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METABOLISM-COUPLED PROTEIN POST-TRANSLATIONAL MODIFICATIONS IN C. ELEGANS AND MAMMALIAN MODELS
… and protein post-translational modifications (PTMs). PTMs are chemical modifications that occur on proteins after their synthesis, enabling rapid and often reversible functional responses to cellular and environmental changes. Most of the hundreds of known PTMs are derived from small molecule …
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NEW METHODS TO QUANTIFY METHIONINE OXIDATION AND PROTEIN GLYCOSYLATION AND A DE NOVO GLYCOPEPTIDE DECOY GENERATOR
Protein post-translational modifications (PTMs) produce complex, heterogeneous species that can best be identified and analyzed using mass spectrometry (MS). The ever-growing number of protein bioetherapeutics need effective MS tools to characterize PTMs and ensure drug safety and efficacy. …
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The evolution, modifications and interactions of proteins and RNAs
… investigating post-translational modifications (PTMs) in RNA-binding proteins (RBPs). By comparing occurrences of PTMs, I observe that RBPs significantly undergo more PTMs than non-RBPs. I also found that within RBPs, PTMs are more frequently targeted at regions that directly interact with RNA …
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Structural Insights into the Mechanisms Controlling the Modification and the Readout of Histone H3.1
… by many post-translational modifications (PTMs). These PTMs serve as epigenetic signals coordinating essential nuclear processes such as transcription, replication and DNA damage repair mechanisms. These marks can be reversibly deposited by specialized "writer" domains in chromatin …
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Proteomic Identification of Histone Post-Translational Modifications Induced By Dna Double-Strand Breaks and Novel Proteins Involved In The Dna Damage Response
… proteins and post-translational modifications (PTMs) involved in DSB repair. In this work, we established a novel method, termed DSB-ChAP-MS (Double Strand Break-Chromatin Affinity Purification with Mass Spectrometry), for the affinity purification of a sequence-specific single copy endogenous …
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Rheologie komplexer Flüssigkeiten
… fluids comprised polymer-surfactant-mixtures (PTMs) and oil-in-water (o/w)-emulsions. The mechanical properties were probed by oscillatory and continuous flow rheometry, microstructures of emulsions were evaluated by optical microscopy while droplet size and droplet size distribution were …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… post-translational modifications (PTM). As PTMs add or subtract a specific mass difference to a protein, mass spectrometry becomes very amenable for modification analysis. These modifications have conventionally been monitored by fragmenting the modified protein or peptide by collision …
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Post-Translational Modification of Proteins via Ambient Air Pollutants and Endogenous Reactive Species
… (RNS) to form post-translational modifications (PTMs), which can affect protein structure and function. The formation of 3-nitrotyrosine (NTyr) and dityrosine (DiTyr) upon reaction of proteins with ROS/RNS are two common PTMs studied due to their stability and irreversibility, as well as their …
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Regulation of pyruvate kinase and glycerol-3-phosphate dehydrogenase in the freeze tolerant goldenrod gall fly: role in polyol cryoprotectant production
… for reversible post-translational modifications (PTMs) to regulate enzyme activity. Several PTMs were analyzed for PK and G3PDH from control and freeze-exposed gall fly larvae using dot-blot analysis. Results showed that low and high phosphate forms of each enzyme exist and these differ in kinetic …
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Investigation of amyloid-β aggregates derived from light-triggered nitration: relevance for Alzheimer’s disease [Indagine sugli aggregati di amiloide-β derivanti dalla nitrazione indotta dalla luce: rilevanza per la malattia di Alzheimer]
… amiloide-β (Aβ) e modifiche post-traduzionali (PTMs) contribuiscono alla genesi di diversi percorsi di aggregazione, risposte infiammatorie e risultati clinici. Tra le PTMs, la nitrazione della tirosina in posizione 10 è stata frequentemente osservata nei cervelli AD, ma il suo significato …
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Integration Of Quantitative And Functional Proteomics To Explore The Global Functional Landscape Of Post-Translational Modifications
… with post-translational modifications (PTMs) expanding proteome complexity and functionality. Significant advancements in mass spectrometry (MS)-based quantitative proteomics have expanded the scope of PTM pathways. Meanwhile, functional proteomics bridges the annotation gap by linking …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… attributed to post-translational modifications (PTMs). In the presented dissertation, I specifically addressed the gap in the molecular mechanisms by which PTMs of ZEB1 regulate its ability to induce EMT and how its activity might be therapeutically targeted. In a previous work from our lab, …
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Post-translational modifications of SEL24K from salmon eggs and ZPA from Xenopus laevis eggs
<p>Post-translational modifications (PTMs) of proteins play significant roles in regulation of biological activities and signal transduction. Examining their diversity is critical for understanding the mechanisms of cellular regulations. Among the various techniques employed for identification of …
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Towards targeted post-translational modification of endogenous proteins in complex environments
… by co- and post-translational modifications (PTMs). Depending on the roles of the modified amino acids and the nature of the chemical changes, PTMs can have tremendous influence on protein function. This phenomenon can be exploited pharmacologically, as covalent inhibitors such as aspirin …
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Chemical Mutagenesis for the Modulation and Study of Protein Function and Dysfunction within Alzheimer’s Disease
… a plethora of post-translational modifications (PTMs), many of which are speculated to have an impact on the pathogenesis of AD as well as other so-called tauopathies. In order to facilitate the accurate study of tau PTMs, an easily accessible method for their site- selective installation is …
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Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
… in wt p53, post-translational modifications (PTMs) drive such drug-induced mutant p53 accumulation and activation. For this purpose, we generated plasmids expressing non-phosphorylatable and phospho-mimic versions of R175H mutant p53 and tested them in different cell line models. We …
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Improved Dynamic Range, Quantitation, and Characterization of Histone H4 Post-Translational Modifications: A Top Down Mass Spectrometric Approach
… through the cell cycle in order to identify PTMs and combinations of PTMs that are associated with cell cycle specific events such as replication and mitosis. The many observed combinations of modifications on H4 led us to develop a novel database searching strategy to simplify data analysis. …
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