Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"PTM"”.
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Pricing-to-market for UK export sector
This thesis investigates the pricing-to-market (PTM) behaviour of the UK export sector. Unlike previous studies, this study econometrically tests for seasonal unit roots in the export prices prior to estimating PTM behaviour. Prior studies have seasonally adjusted the data automatically. This …
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Systemic analysis of changes in protein modification and gene coexpression networks in cancer
Perturbed posttranslational modification (PTM) landscapes and gene expression networks commonly cause pathological phenotypes. To elucidate altered PTM landscapes on a large scale, disease-associated mutations from TCGA, Uniprot, and dbSNP were integrated with PTM sites from PhosphoSitePlus. We …
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Prediction of Tonal Acoustic Radiation Due to Feedback-Loop Resonant Interactions in Transitional Airfoils
… airfoil. The Potential-Theoretic Method (PTM) as an advancement to traditional Kirchhoff methods is presented. The PTM eliminated the need to calculate the normal derivatives of pressure and an arbitrary Kirchhoff surface can be employed. The numerical procedure to implement the PTM is …
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From Technology to Chromatin Biology: Contemporary Mass Spectrometry of Histones and Chromatin Associated Proteins
… which analyzes large peptides to characterize PTM profiles on histone H3. Interestingly, we were able to conclude that methylation and acetylation levels on histone H3 are highly effected by perturbations of DNA methylation. In the past years we have expanded the applications of top down and …
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Integration Of Quantitative And Functional Proteomics To Explore The Global Functional Landscape Of Post-Translational Modifications
… with post-translational modifications (PTMs) expanding proteome complexity and functionality. Significant advancements in mass spectrometry (MS)-based quantitative proteomics have expanded the scope of PTM pathways. Meanwhile, functional proteomics bridges the annotation gap by linking …
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Evolutionary, structural and functional features of cellular signalling networks
… and disease. Post-translational modifications (PTMs) can dynamically diversify the proteome in response to intracellular and extracellular signals. Since thousands of modified residues as well as entirely new modification types have recently been discovered in proteins, elucidating their …
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Investigating the Post-Translational Modification of Notch1 Intracellular Domain: From Proteolytic Cleavage to Mass Spectrometric Profiling
… cancer. Thus, post-translational modifications (PTM) further fine-tune Notch activity by modulating its trafficking, stability, and transcriptional dynamics. This thesis investigates the post-translational regulation of the Notch1 intracellular domain (N1ICD), focusing on its potential …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… by different post-translational modifications (PTM). As PTMs add or subtract a specific mass difference to a protein, mass spectrometry becomes very amenable for modification analysis. These modifications have conventionally been monitored by fragmenting the modified protein or peptide by …
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METABOLISM-COUPLED PROTEIN POST-TRANSLATIONAL MODIFICATIONS IN C. ELEGANS AND MAMMALIAN MODELS
… and protein post-translational modifications (PTMs). PTMs are chemical modifications that occur on proteins after their synthesis, enabling rapid and often reversible functional responses to cellular and environmental changes. Most of the hundreds of known PTMs are derived from small molecule …
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Analysis of enzymatic L/D-peptide isomerization in animals
… result from a post-translational modification (PTM) in which an L-amino acid residue is enzymatically converted into a D-amino acid residue in the peptide chain. Isomerization leads to important changes in the three-dimensional structure and bioactivity of the DAACP and increases its resistance …
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Database support for top-down proteomics
… critical role as the data warehouse for ProSight PTM, the first publicly available top-down proteomics software suite. MySQL, a free relational database, was the base of this warehouse. Many annotated and predicted protein forms have been successfully incorporated into the organism-specific …
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Post-translational modification of proteins secreted by Pseudomonas aeruginosa and its role in bacterial physiology
… also through post-translational modification (PTM). By understanding the nature of PTM in extracellular proteins and how these may affect protein function and stability, a future platform for alternative anti-virulence interventions can be developed. In this dissertation I first looked at how …
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Examining Post-Translational Modifications In Alpha-Synuclein Through Semi-Synthesis And Single Molecule Spectroscopy
… A variety of post-translational modifications (PTMs) are known or hypothesized to affect both the function of αS and its propensity to form fibrils. In this work, we introduce PTMs of interest along with fluorescent probes into αS through semi-synthesis, affording site-specifically modified αS …
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Factors affecting post-thaw quality of cryopreserved boar sperm and its effect on gilt fertility
… samples were evaluated for post-thaw motility (PTM), viability (VIA), and intact acrosomes (IA) at 5, 30, and 60 min. Data were analyzed using the MIXED procedures of SAS for the effects of temperature, duration of thawing, and boar. There was an effect of treatment (P < 0.0001) on PTM, VIA, and …
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A Periodic Table of Movements: Two Reference Frameworks for Quantifiable Emotion, A Practice Based Investigation of Human Expressive Movement and Gesture
… defined as the Periodic Table of Movements (PTM) and a PTM database. The PTM database is a synthesis of embodied emotion data derived from multiple visual representations such as colour, shape, space, volume, time and intensity, whereas the relationship between expressions is visualised in …
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Interrogation of Yeast Responses to Anaerobic Growth Conditions at the Intact Protein Level Using Improved Top-Down Proteomics
… and anaerobic isoform. Direct comparison of PTM patterns between two cell states was also accomplished through top-down proteomics.
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Bioinformatic methods for the analysis of genetic variability and regulation
… histone post-translation modifications (PTM), and regulation of functional genomic elements. Histone marks control much of the workings of the genome. However, it remains unclear how different histone PTM combine within individual nucleosomes to encode regulatory information. Regular …
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Protein LC-MS Using Slip Flow Chromatography
… variants and post-translational modifications (PTMs). PTM levels of histones are known to correlate with different stages of cancer. Due to the lack of resolution on intact histone separations, conventional methods for histone analysis require time-consuming digestion, which often leads to the …
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Beam-Based Target Alignment for Mu2e
… to within 0.5 mm. The production target monitor (PTM) will ensure this alignment.</p> <p>The PTM consists of a series of proportional wire chambers (PWC’s) upstream and downstream of the production target. In this dissertation, I explain the requirements of this detector system and derive the …
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Characterization of Post-translational Modifications and Resulting Structure/Function Relationships of Recombinant Human Factor IX Produced in the Milk of Transgenic Pigs
… its numerous post-translational modifications (PTMs), including gamma-carboxylation, proteolytic maturation, phosphorylation, sulfation, and glycosylation. Of these PTMs, those known to be vital for activity are gamma-carboxylation of multiple glutamate residues near the N-terminus and …
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