Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PTHrP"”.
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
Parathyroid hormone-related protein (PTHrP) is expressed by prostate cancer cells. Since PTHrP enhances the growth and osteolytic potential of prostate cancer cells, it is important to control PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in …
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Expression and Function(s) of Parathyroid Hormone- Related Peptide in Intramembranous Bone Formation by Neonatal Rat Calvarial Cells In Vitro
… absence of parathyroid hormone- related peptide (PTHrP) established that the peptide is necessary for normal development and growth of the skeleton. The shortening of appendicular bones in knockout mice is explained by an effect of PTHrP on endochondral bone growth where it functions to inhibit …
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Expression of epithelial and neuroendocrine markers within canine apocrine gland anal sac adenocarcinoma (AGASACA) and the relationship to peripheral hypercalcemia and parathyroid hormone-related protein (PTHrP) expression
… elevated parathyroid hormone-related protein (PTHrP). As the tumor name implies, this neoplasm is attributed to apocrine gland origin, and special staining is not typically performed for additional investigation. Few studies have pursued additional characterization of these masses and …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… injury. Parathyroid hormone related protein (PTHrP) is a pro-inflammatory and pro-fibrotic mediator of acute and CP. The first aim was to identify PTHrP-related mechanisms by which apigenin limits inflammation in acinar cells. Apigenin reduced activation of the MAPK/ERK and NF-κB pathways, …
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Expression und Regulation 1,25(OH) 2 -Vitamin D 3-responsiver Gene in monozytären Zellen
… Ligand des PTHR1 ist PTH related Protein (PTHrP), ein Faktor der die Tumorhyperkalzämie propagiert. Durch Markierungsexperimente mit fluoreszenz-markiertem PTHrP konnte gezeigt werden, dass PTHrP an die Zellmembran von PBM und Dendritischen Zellen bindet und in den Zellkern von …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… factor for p-smad2 to activate PTHrP expression and bone osteolytic effect. Taken together, we reveal a novel mechanism that 14-3-3ζ dictates the tumor suppressor or metastases promoter activities of TGF-β signaling pathway through switching p-smad2 binding partner from p53 to …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… non-inhibitory effect of individual genistein on PTHrP is lost in the presence of TGFβ but continues with significant decrease with snail. The non-inhibitory effect of coumestrol on PTHrP and snail genes expression altered to reduced significantly which suggest a strong effect of TGFβ on …
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
… cells to secrete pro-osteolytic factors (e.g., PTHrP), resulting in more osteoclast-mediated bone resorption. Curcuminoids, dietary polyphenols derived from the turmeric rhizome, inhibit progression of osteolytic bone metastases and other resorptive diseases by targeting osteoclasts and – in the …
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PTH RESISTANCE SYNDROMES: AGE-DEPENDENT CLINICAL PICTURE AND EMERGING UNCOMMON FEATURES
… the diseases caused by mutations within the PTH/PTHrP signaling cascade (iPPSD). PTH resistance is the hallmark of these disorders, but clinical picture is wider and more complex, with high variability and age-dependent presentation. A diagnostic delay is commonly reported; thus, our studies aim …