Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PTEN-null"”.
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
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Small Molecule Regulator of ENTPD5, and ER Enzyme in the PTEN/AKT Pathway
… proliferation and survival. Tumor supressor gene PTEN encodes a lipid phosphatase that antagonizes PI3K function and consequently inhibits downstream signaling through Akt. Dysregulation of this pathway has been found in a variety of human cancer, mainly by loss of function of PTEN, or …
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The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN
PI3 Kinase and PTEN lipid phosphatase control the level of cellular phosphatidylinositol (3,4,5)-trisphosphate, an activator of AKT kinase that promotes cell growth and survival. Mutations activating AKT are commonly observed in human cancers. Activation of AKT and downstream PI3 Kinase signaling …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… tumour-suppressor and PI(3,4,5)P3-3-phosphatase PTEN, or modified to a distinct PI(3,4)P2 signal, by SHIP-family 5-phosphatases. The PI(3,4)P2 is removed by INPP4-family 4-phosphatases. Published work has shown that PI(3,4,5)P3 signalling can also occur in endosomes and nuclei, however, there is …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… in key pathway genes (e.g., *PIK3CA*, *PTEN*). Despite extensive research, the primary drivers of healthy or oncogenic PI3K signalling *in vivo* are largely unknown and PI3K pathway inhibitors show limited clinical benefit in solid tumours. Identifying upstream regulators of oncogenic …
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1á,25(OH)2-VITAMIN D3 IN PROSTATE: INTERSECTION WITH AKT/PTEN AXIS AND ROLE IN SENESCENCE
… occurs due to the loss of tumor suppressor PTEN, we evaluated the effect of Pten loss on 1á,25(OH)<sub>2</sub>D<sub>3</sub>)-mediated antiproliferative effects utilizing mouse prostatic epithelial cells (MPEC) with acute in vitro Pten knockdown or knockout. We found that loss of Pten …
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The AMPK signalling pathway in cancer and DNA damage
… of AMPK in cancer. T cell-specific deletion of PTEN in mice causes development of T cell lymphomas at a median age of 85 days (43-214 days), while T cell-specific deletion of AMPK as well as PTEN caused development of lymphomas much sooner, at a median age of 65 days (46-87days, p<0.0001, hazard …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… significant promise for cancer therapy. The PTEN tumor suppressor governs a variety of biological processes, including metabolism, by acting on distinct molecular targets in different subcellular compartments. In the cytoplasm, PTEN regulates a plethora of metabolic processes through …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
The PTEN tumour suppressor is the second most frequently mutated tumour suppressor gene in cancer. It is a lipid and protein phosphatase that negatively regulates the well-known pro-proliferative and anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell …