Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"PTEN Phosphohydrolase"”.
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… (e.g. EGFR amplification/activation, PTEN loss, p53 loss, Ink4a/Arf loss). How these genetic changes may modulate responses to radiation and chemotherapy is not well understood. To elucidate this relationship, genetically defined mouse models have been used for both in vitro and in …
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The PI3-Kinase/TSC Pathway: A Role in Neural and Renal Development and Pathology
PTEN is a tumor suppressor gene and its protein product negatively regulates the PI3K/AKT pathway through counteracting the kinase function of PI3-Kinase. Loss of function of PTEN results in overactivation of AKT and in turn activates multiple AKT downstream pathways. One AKT substrate is the …