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Showing 1 to 20 of 170 for “"PTEN"”.
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… and Tensin Homologue on chromosome Ten (PTEN) is a tumor suppressor and an antagonist of the phosphotidylinositol-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base-pairs …
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The molecular mechanisms of pseudogene-mediated PTEN expression.
The phosphatase and tensin homolog, PTEN, is a protein that negatively regulates the PI3K-Akt pathway through its phosphatase activity. PTEN is a tumour suppressor gene and mutations to the PTEN gene are often a precursor to the development of cancerous cells, common in many different types of …
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Pten Function in Postnatal Brain Development and Tumorigenesis
<p><em>PTEN</em> (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase …
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Studies of the PTEN tumour suppressor in endometrial cancer.
Somatic mutations in the PTEN gene (Phosphatase and Tensin Homologue Deleted on Chromosome Ten) have been found in many types of cancer, but most frequently in cancer of the endometrium.The PTEN gene encodes a D3 lipid phosphatase of the second messenger phosphatidylinositol 3,4,5-trisphosphate …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
… study, we determined the role of the phosphatase PTEN in Treg cells. We found that specific depletion of PTEN in Treg cells results in excessive TH1 and T follicular helper cells (TFH) responses, associated with elevated germinal center (GC) B cells and spontaneous development of autoimmune and …
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P53R245W Mutation Elicits Metastatic Phenotype In Pten Deficient Prostate Cancer
… prostate-specific p53R245W mutant and Pten deletion to access the role of this common p53 mutant in the pathogenesis and metastasis of prostate cancer. We found that <em>Trp53<sup>R245W/-</sup> Pten<sup>-/-</sup></em> mice have invasive prostate cancer with complete penetrance and …
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… kinase Akt via an oxidative inhibition of PTEN by S-nitrosylation. During the course of this study, it was noticed that in mouse embryonic fibroblasts that do not express the tumour suppressor PTEN (MEFPTEN-/- cells), a decrease in the intracellular level of O2.- abrogated the …
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PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
… lines HCT116 and SW480 were transfected with PTEN siRNA or non-targeting control. Invasiveness was measured using a modified Boyden chamber assay and migration was assessed using a scratch assay. Results. PTEN knockdown increases the invasion and migration of CRC cells and the addition of …
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Microenvironment-Induced Pten Loss By Exosomal Microrna Primes Brain Metastasis Outgrowth
… primary tumor cells with normal expression of PTEN, an important tumor suppressor, lose PTEN expression after dissemination to the brain, but not to other organs. PTEN level in PTEN-loss brain metastatic tumor cells is restored after leaving brain microenvironment. This brain …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… significant promise for cancer therapy. The PTEN tumor suppressor governs a variety of biological processes, including metabolism, by acting on distinct molecular targets in different subcellular compartments. In the cytoplasm, PTEN regulates a plethora of metabolic processes through …
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INTERACTION OF PTEN DELETION AND C-MYC GAIN IN PROSTATE CANCER PROGRESSION
Prostate cancer is of significant public health importance since it is the most common non-cutaneous cancer and the second leading cause of cancer death among men in the United States. While the majority of prostate cancer patients will not die of the disease and some may not even need treatment, …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… and tensin homologue on chromosome 10 (PTEN). The cre-lox system was used to eliminate RIM1 from the hippocampal dentate gyrus and area CA3, while adeno-associated virus expressing PTEN-directed interference RNA was injected into the basolateral amygdala to knockdown PTEN in local …
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Small Molecule Regulator of ENTPD5, and ER Enzyme in the PTEN/AKT Pathway
… proliferation and survival. Tumor supressor gene PTEN encodes a lipid phosphatase that antagonizes PI3K function and consequently inhibits downstream signaling through Akt. Dysregulation of this pathway has been found in a variety of human cancer, mainly by loss of function of PTEN, or …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size …
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A Role for Insulin Signaling in Regulating the PTEN Tumour Suppressor in Caenorhabditis Elegans
… and cancer risk is not well understood. PTEN plays an antagonistic role in the canonical insulin signaling pathway, and is the second most commonly mutated tumour suppressor (after p53) found in human cancers. In many cancers the PTEN gene is not deleted, but instead the protein is lost. …
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Jab1 Negatively Regulates Pten and Promotes Resistance to Trastuzumab In Her2-Positive Breast Cancer
… can occur through reduced expression of PTEN protein.</p> <p>Jab1 is over-expressed in 50% of primary cancers and 90% of metastatic tumors. Our lab previously showed that depletion of Jab1 in combination with trastuzumab treatment up-regulated PTEN in mouse xenografts refractory to …
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
… of which correspond to a significant increase in PTEN. We also found that PRL 2 is targetable by small molecular inhibitors that can potentially be used to disrupt tumor growth and spermatogenesis. Furthermore, a PTEN heterozygous mouse model crossed into our PRL 2 knockout line was generated to …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
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P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis
PTEN, a tumor suppressor lost in multiple cancers, antagonizes PI3-kinase signaling by dephosphorylating the second messenger phosphatidylinositol (3,4,5) trisphophate. PTEN expression and enzymatic activity is regulated through various mechanisms, including oxidation, phosphorylation, and …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
The PTEN tumour suppressor is the second most frequently mutated tumour suppressor gene in cancer. It is a lipid and protein phosphatase that negatively regulates the well-known pro-proliferative and anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell …
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