Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PTBP1"”.
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… of the RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 contribute to AS changes. Utilizing genome-wide approaches, we identified extensive changes in AS patterns in T1D mouse hearts. We discovered that many aberrantly spliced genes in T1D hearts have CELF1 and PTBP1 binding sites. …
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Elucidating the roles of endothelial PTBP1 and PKM2 in Pulmonary Arterial Hypertension: implications for therapy
… factor Poly-pyrimidine tract binding protein 1 (PTBP1) and its gene product, the glycolytic enzyme Pyruvate Kinase M2 (PKM2). Moreover, normal EC function and metabolism is restored by PTBP1 silencing, highlighting the therapeutic potential of targeting PTBP1 and PKM2. In this thesis, I have …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… Here we show how the RNA-binding protein PTBP1 is dispensable for T cell development but has an essential role in regulating CD8 T cell activation, proliferation, and production of effector molecules. To investigate the roles of PTBP1 in CD8 T cells we generated a mouse model which …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… of MYCN to promoter regions of splicing factors PTBP1 and HNRNPA1, demonstrating that MYCN regulates splicing by directly regulating expression of key splicing factors. Furthermore, high expression of PTBP1 and HNRNPA1 was significantly associated with poor overall survival of stage 4 NBL …
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Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
… diabetic heart identified targets of CELF1 and PTBP1 that are mis-spliced. Interestingly we found evidence that diabetes induced alterations in RBFOX2, CELF1, and PTBP1 coordinately regulate AS changes. In skeletal muscle similar pathogenic changes in AS occur and correlate with an increase in …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… protein polypyrimidine tract-binding protein 1 (PTBP1), unveiling a PACS-1 nuclear trafficking function. Second, we defined a role for PACS-1 orchestrating intracellular calcium levels within corticotropic cells. We establish PACS-1 interactions with transient receptor potential cation channel 3 …
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LINE1 MODULATE HUMAN T CELL FUNCTION BY REGULATING PROTEIN SYNTHESIS DURING LIFE SPAN
… e alla soppressione dello splicing mediata da PTBP1. L'assenza di espressione di LINE1 facilita la predisposizione di queste cellule a un’attivazione rapida attraverso la regolazione diretta della sintesi proteica. L'espressione di LINE1 aumenta progressivamente durante l'infanzia e l’età …
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Transcriptional and post-transcriptional regulation in tissue regeneration and disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01