Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"PSMA"”.
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Biochemical and Molecular Characterization of the Prostate-Specific Membrane Antigen (PSMA)
… named the prostate specific membrane antigen or PSMA. Antibody-radionuclide conjugates of 7E11-C5.3 have been successfully used to localize metastatic disease in vivo and treat human prostate tumors in nude mice suggesting that PSMA may have promise as an important new diagnostic and therapeutic …
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Optimizing PSMA scintigraphy for resource limited settings – a retrospective comparative study
Methods: The scans of 95 patients with histologically proven PCa who underwent PS with full-body planar and multi-FOV SPECT/CT were reviewed. The detection rates for uptake in the prostate gland/bed and in metastases were compared on planar, SPECT, and SPECT/CT. The agreement between modalities was …
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Prostate Specific Membrane Antigen (PSMA): Immunoassay Development and Characterization of Transcriptional Regulation
… designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a clinically useful immunoassay for quantitation of serum PSMA and to study the molecular mechanism underlying the upregulation of the PSMA gene after androgen …
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Herstellung und Charakterisierung rekombinanter Immunotoxine aus anti-PSMA single-chain Antikörperfragmenten zur Therapie des Prostatakarzinoms
… <br>Das Prostataspezifische Membranantigen (PSMA), welches als Dimer an der Oberfläche von Prostata-Epithelialzellen vorliegt, stellt ein hervorragendes Zielantigen für eine Prostatakarzinom-Therapie dar, denn es ist a) hauptsächlich in der Prostata exprimiert, b) in hohem Maße als Protein in …
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Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as a complementary linker to attach chemical moieties to siRNA. In Chapters 1 and 2, we introduced and discussed the background of …
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Synthetic analogues of protein-lipid complexes
Hypercoiling poly(styrene-alt-maleic anhydride) (PSMA) is known to undergo conformational transition in response to environmental stimuli. The association of PSMA with lipid 2-dilauryl-sn-glycero-3-phosphocholine (DLPC) produces polymer-lipid complex analogues to lipoprotein assemblies found in …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… known as prostate-specific membrane antigen (PSMA) and creates opportunities for precision medicine approaches. Using PSMA as a mechanism of disease selection, I conceptualized, designed, coordinated and contributed to the synthesis of, and tested a precision chemotherapy with on-demand …
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Carbon nanotube assisted formation of sub-50 nm polymeric nano-structures
… substrates. Poly(styrene-alt-maleic anhydride) (PSMa) was prepared by the initiated chemical vapor deposition (iCVD) method, an alternative to spin-on deposition. The sub-50 nm PSMa polymer patterns were prepared by low energy oxygen plasma etching by using CNTs as the masks. The water soluble, …
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Evaluating the role of a 99mTc-HYNIC-PSMA SPECT scan following a negative bone scan in men with prostate cancer: a single-centre, retrospective cohort study
… prostate cancer, who had a 99mTc-HYNIC-PSMA SPECT (technetium-99m hydrazine nicotinamide prostate-specific membrane antigen singlephoton emission computerised tomography) scan following a negative 99mTc-MDP (technetium-99m methylene diphosphonate) bone scan. Materials and methods: This …
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DUPA α-Amanitin Conjugates for Targeted Prostate Cancer Therapy - Optimization and Evaluation of In Vivo Potency
… in men. The Prostate Specific Membrane Antigen (PSMA) attracted a great attention as a target for the development of personalized therapeutics. Out of two PSMA targeted antibody-drug conjugates (ADCs) in clinical development none up to the moment reached the market approval due to limited …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… study also focused on developing an optimized PSMA-targeted liposomal delivery system to improve drug accumulation in CRPC tumors while minimizing systemic toxicity. Given the overexpression of prostate-specific membrane antigen (PSMA) in advanced prostate cancer, Eupenifeldin-loaded liposomes …
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α-Amanitin-based Small Format-Drug Conjugates for Prostate Cancer Therapy: Enabling Anti-Tumor Activity by Tuning Pharmacokinetic Properties
… affinity to Prostate Specific Membrane Antigen (PSMA), a validated target of virtually all prostate cancers. α-Amanitin, a natural toxin isolated from the green death cap mushroom Amanita phalloides, which acts as potent RNA polymerase II inhibitor of eukaryotic cells, was investigated as …
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Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
… indices, (ii) conjugation of a ligand( PSMA antibody) on the surfaces of nanomicelles to ensure selectivity and targeted delivery, (iii) Optimization of parameters such as drug-to-polymer ratio on experimental design using JMP software and, (iv) determination of pentablock stability at …
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Novel antimicrobial combinations for treatment against pathogens associated with infected diabetic foot ulcers
… an annulus of polystyrene-co-maleic anhydride (PSMA). PSMA is used extensively in structural biology to extract lipids and stabilize integral membrane proteins for biophysical studies. Also, the use of enzymes has been shown to degrade extracellular polymeric matrices which can improve the …
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Synthesis and evaluation of novel non-viral gene delivery systems for prostate cancer targeting
… receptors, prostate specific membrane antigen (PSMA) and integrins areoverexpressed on prostate cancer cells, the purpose of this study is to determine whether lactoferrin, Peptide2 (CWQPDTAHHWATL) and Peptide4 (CPRPRGDNPPLTCGGKKK) bearing diaminobutyric polypropylenimine (DAB) based dendriplexs …
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Development of new radiopharmaceuticals targeting the Cholecystokinin 2 receptor
… a fini clinici, tra questi da segnalare [68Ga]PSMA-11 e [18F]PSMA-1007 che grande importanza stanno acquisendo in diagnostica PET (Positron Emission Tomography) nella stadiazione del tumore della prostata soprattutto nel rivelare la ripresa di malattia in pazienti con bassi livelli di PSA. …
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Balancing Antitumor Efficacy and Safety Profile: α-Amanitin-Based Fc-Small Molecule Drug Conjugates for Targeted Prostate Cancer Therapy
… binds to the prostate-specific membrane antigen (PSMA) highly expressed on prostate cancer cells, Fc-fragment for half-life extension, and Amanitin as a toxin bearing a cleavable linker. This conjugate showed good in vivo efficacy; however, because of the low tolerability, the therapeutic index …
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Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
… (PSA), Prostate Specific Membrane Antigen (PSMA) and Prostatic Acid Phosphatase (PAP) were inhibited by a novel GR inhibitor. Thus, this GR inhibitor could be used in combination with enzalutamide and create a more potent AR signaling blockade. Prostate cancer is a very problematic disease …
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Drug Delivery Strategies Using Light Sensitive Molecules
… of them such as Folic Acid Receptor (FAR) and PSMA (Prostate Specific Membrane Antigen) are overexpressed in malignant cells. In our new designs, we attached folic acid and urea based (DUPA) ligand, which were previously reported to bind to FAR and PSMA receptors respectively. Cell studies are …
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Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… binds to prostate-specific membrane antigen (PSMA) with a high affinity. The micelle showed a low critical micelle concentration (CMC), high drug loading, and high entrapment efficiency. The release of cabazitaxel from the micelle is dependent on the cleavage of the enzyme-responsive peptide …
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