Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PSGL-1"”.
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Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)
… acids of P-selectin glycoprotein ligand- 1 (PSGL- 1). Three rounds of engineering were performed after an initial pool of binders was isolated from a non-immune scFv library. Chain shuffling was found to be important for generating an improved mutant in the first round of engineering.
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Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
… glycoprotein ligand-1/mouse immunoglobulin G2b (PSGL-1/mIgG2b) together with glycosyltransferases that are known to mediate the biosynthesis of specific carbohydrate determinants. PSGL-1/mIgG2b, which we have proposed as a versatile inhibitor of protein–carbohydrate interactions, consist of the …
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APPROACHES TO IDENTIFY SURFACE PROTEINS OF ANAPLASMA PHAGOCYTOPHILUM DENSE-CORED ORGANISMS AS ADHESINS TO HUMAN P-SELECTIN GLYCOPROTEIN LIGAND-1
… P-selectin glycoprotein ligand-1 (PSGL-1) is the confirmed receptor utilized by A. phagocytophilum to bind and invade human neutrophils and myeloid cell lines. As an obligate intracellular pathogen, the binding of A. phagocytophilum to a host cell receptor is a prerequisite step for …
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Characterization of the biochemical and biophysical mechanisms fundamental to receptor-mediated white blood cell accumulation.
… interactions mediated by L-selectin and PSGL-1 enhance accumulation of cells. We have recreated these initial cell recruitment events in vitro using simplified systems. We have identified a novel mechanism that enables cell-cell interactions to occur which may contribute in the …
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Role of Monocytes and Neutrophils in Thrombosis
… between platelet P-selectin and its receptor PSGL-1 found on monocytes was identified as both necessary and sufficient to induce this event. The process was successfully inhibited with P-selectin and PSGL-1 blocking antibodies and could be induced in isolated monocytes by the addition of …
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Einfluss der Inhalationsanästhetika Sevofluran und Desfluran auf die Ausbildung von Adhäsionsmolekülen auf Granulozyten in vitro
… affect the activation of the selectins PSGL-1 (CD162) and L-selectin (CD62L) and the b2- integrins CD11a and CD11b. Whole blood was incubated for 60 minutes with 1 or 2 MAC (minimum alveolar anesthetic concentration) sevoflurane or desflurane. After incubation, neutrophils and monocytes …
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The pathogenesis of idiopathic pulmonary fibrosis
… Moreover, expression of CD40L, P-selectin and PSGL-1 on platelets and subpopulation of leukocytes suggested that platelet expression of these molecules is not significantly different in IPF as compared to ILD other than IPF or non-ILD controls. Furthermore, platelet mediated injury hypothesis …