Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"PSD95"”.
-
NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the PSD95-nNOS interaction attenuates fear consolidation and impairs long-term potentiation of basolateral amygdala (BLA) neurons in a rodent model of …
-
Synaptome mapping of glutamatergic synapses across the mouse brain
… the DLG family, postsynaptic density protein 95 (PSD95) and synapse associated protein 102 (SAP102), have been shown to form different types of complexes, thus giving the synapse different signalling capabilities. However, the spatial distribution of these synaptic markers in different synapses …
-
Three-Dimensional Single-Molecule Localisation Microscopy and Visualisation Techniques
… protein known as postsynaptic density 95 (PSD95). PSD95 is known to form nanoclusters which make up the basic structural unit of an excitatory synapse, however, through the sensitivity of 3D DH-PSF imaging, we were able to observe the presence of diffuse PSD95 protein. We have developed a …
-
Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… MAGUKs (Membrane associated guanylate kinases) PSD95, SAP102 and PSD93, one of which (PSD95) is regulated by FMRP (Zalfa et al., 2007) and the others which have putative binding sites for FMRP. MAGUKs tether glutamatergic receptors to their associated signalling complexes at the postsynaptic …
-
Nociception and the Experience of Pain Signaling Due to Nerve Damage
… labeled NMDA receptors for glutamate and PSD95 clustering proteins for NMDAr at integration and motor synapses of spinal cord tissues. The FIM values were then correlated to the presence of NMDA, or PSD95 on spinal neurons to indicate production and assembly of glutamatergic synapse …
-
Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… with host post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (ZO-1) (PDZ) domain-containing proteins, facilitating immune dysregulation and hyperinflammation. Early work on SARS-CoV-1 revealed that the PBM of its E protein …
-
Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… decreased expression of the postsynaptic protein PSD95, but no decrease in the presynaptic protein synaptophysin, in the hippocampus. I did not detect a significant decrease in mitochondrial function or morphology in brain synaptosomes, myelination in the cingulate cortex using Black Gold II …
-
Experience-dependent dendrite remodeling of GABAergic interneurons in the adult visual cortex
… be visualized by tagging fluorescent proteins to PSD95 and Gephyrin, respectively. Finally, we show that the fluorescent proteins, Teal and Venus, can be simultaneously excited and spectrally resolved through linear unmixing so that individual structural and synaptic components can be identified …
-
Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… other neuronal substrates such as SNAP25, PSD95 and GAD65. By contrast, mutant htt does not act this way, probably due to lack of interaction with HIP14. Furthermore, immunoprecipitated HIP14 from huntingtin+/- mice also exhibits less enzyme activity in palmitoylating GST-SNAP25 in vitro, …
-
Accelerated Ovarian Failure Causes Neuronal Detriments in the Menopausal Transition that are not Recovered by High Intensity Interval Training
… and synaptic markers such as NeuN, SNAP25, PSD95 and BDNF. Mice that received VCD had lower discrimination index (%) on the NORT alongside lower SNAP25 and NeuN. Mice that received VCD in combination with exercise had no improvements in cognition, however, they had lower activity of AD …
-
Structural Modes in Proteins: A Case Study in the PDZ Domain
… protein (the third PDZ domain from rat PSD95) by measuring physical interactions between all pairs of residues. This global perturbation analysis is performed by making evolutionarily conservative mutations at every position in a protein and observing physical effects by monitoring a …
-
Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
… These include binding of scaffolding proteins PSD95 and JIPs to an alternatively spliced exon within the cytoplasmic tail of Apoer2, which is not found in any other LDLR family member. This exon has been shown to mediate increased LTP induction after Reelin stimulation. Apoer2 knockin animals, …
-
Einfluss der GTPase RhoA auf die axonale Regeneration und die Erholung der Funktion von Neuronen in organotypischen Kulturen
… einen Einfluss von RhoA auf das Membranprotein PSD95. Dieses Protein reguliert nicht nur die Verankerung von NMDA-Rezeptoren in der Zellmembran, sondern vermutlich auch einen dem NMDA-Rezeptor nachgeschalteten Signaltransduktionsweg. Es wäre denkbar, dass RhoA über diesen Weg die striatale …
-
Identifizierung und Charakterisierung entwicklungsabhängig hochregulierter Gene im Innenohr der Ratte
… Cod106 mit dem postsynaptischen Markerprotein PSD95 kolokalisiert, wodurch auf eine eindeutig postsynaptische Lokalisation von Cod106 geschlossen werden kann. Das zellspezifische Expressionsmuster und die subzelluläre Lokalisation dieses Proteins wären mit einer spezifischen Funktion in …
-
Role of the different domains of PSD-95 in basal synaptic transmission
… in Verbindung mit der GK-Domäne des PSD95 für die funktionale Regulation von AMPA-Rezeptoren notwendig sind, wohingegen dessen SH3- und PDZ3-Domäne dabei nur eine unterstützende Rolle zuzuordnen ist.
-
Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease
… the synapse, such as Post-synaptic density 95 (PSD95), synapsin I, and brain-derived neurotrophic factor (BDNF), among others. Confocal imaging demonstrated rescued dendritic spines with 17-AAG treatment after Aβ challenge in neuronal culture models. The functionality of these changes in the …
-
Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… amygdala were evaluated for GluA1-3, PKMz and PSD95.</p> <p>We found that:</p> <p>(1) As expected, both juvenile and adults have intact threat memory retrieval 24 hours post-training. However, at 7 days post-training only adults exhibit a sustained threat memory</p> <p>(2) GluA1-2 AMPAr …
-
LEPTIN SIGNALING IN AN ANIMAL MODEL OF ANOREXIA NERVOSA: EVIDENCE FOR (MAL)ADAPTIVE PLASTICITY IN REWARD- AND COGNITIVE-RELATED BRAIN AREAS
… spine mature, che, insieme a livelli ridotti di PSD95 e Neuroligin-1, indicano una riorganizzazione delle strutture sinaptiche ippocampali. In concomitanza con questa alterazione strutturale, abbiamo osservato un aumento della localizzazione delle subunità dei recettori NMDA e AMPA sia nella …