Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"PSD-95"”.
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Impaired and enhanced spatial representation of the PSD-95 knockout mouse
Postsynaptic density protein-95 (PSD-95) is the second most abundantly expressed synaptic protein in the postnatal forebrain. It is an integral part of the postsynaptic scaffolding complex and helps recruit receptors, channels and associated factors involved with synaptic transmission. A mouse …
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Role of the different domains of PSD-95 in basal synaptic transmission
… reguliert. Deren Funktion wird durch PSD-95 reguliert, das zusammen mit PSD-93, SAP97 und SAP102 zur Familie der DLG-MAGUK-Proteine gehört. DLG-MAGUK-Proteine ähneln sich strukturell in der Anordnung von funktionalen Protein-Domänen. Sie haben 3 PDZ- Domänen, eine SH3- Domäne und eine …
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Isothermal Titration Calorimetry Studies Of Protein-Mediated Interactions And Preliminary Structural Studies Of Tandem Pdz1-2 Domain Of Psd-95 Protein
… the dual domain PDZ1-2 of postsynaptic density-95 kDa (PSD-95) protein, a mammalian neuronal protein. The individual constructs, PDZ1 and PDZ2, were also prepared for comparative studies. Challenging the individual PDZ1 and PDZ2 and dual domains with short peptides derived form the C-terminal …
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Imaging Neuromuscular Synaptogenesis
… synaptic type. Biochemical studies reveal that PSD-95/Dlg family scaffolding proteins could coordinate postsynaptic molecular assembly at glutamatergic synapses. Genetic studies demonstrate their role during synaptic maintenance and plasticity. However, it is unclear whether initial …
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Charakterisierung von Somatostatinrezeptor-Subtyp 4 interagierenden Proteinen in der Ratte (Rattus norvegicus)
… spezifisch mit dem SSTR4 interagieren. Sowohl PSD-95 als auch PSD-93 (Postsynaptic density protein of 95 kDa bzw. 93kDa) wurden mit einem immobilisierten Peptid präzipitiert, das die neun C-terminalen Aminosäuren des SSTR4 enthält. Die Interaktion des SSTR4 mit PSD 95 wurde im Weiteren näher …
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Expression and function of PSD-93 isoforms in hippocampal synapses
… (AMPARs) in der postsynaptischen Verdichtung (PSD) ab. PSD-95 ist das prototypische Ankerprotein in der PSD, dem eine wichtige Rolle für die Funktion von AMPARs zugesprochen wird. PSD-95 gehört zu der Proteinfamilie der PSD-MAGUKs, zu der auch die Proteine SAP97, SAP102 und PSD-93 gehören. Die …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… phosphorylates the postsynaptic scaffold protein PSD-95, a major determinant of synaptic strength, at the Thr- 19 residue. In hippocampal neurons, this promotes the activity-dependent dispersal of synaptic PSD-95 clusters. We found that overexpression of a phospho-null mutant (Ti 9A-PSD-95), but …
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The investigation of the neuronal and synaptic defects in early stage of amyloid-beta pathology
… which A elevates postsynaptic density protein 95 (PSD-95), promoting seizure response in young APP/PS1 mice. This elevation results from reduced ubiquitination caused by Akt-dependent phosphorylation of E3 ubiquitin ligase murine-double-minute 2 (Mdm2). PSD-95 is required for facilitating …
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Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… were unextractable. The synaptic clustering of PSD-95, a putative NMDA receptor anchoring protein and a core component of the postsynaptic density (PSD), was unaffected by actin depolymerization, microtubule depolymerization, or detergent extraction. The same was largely true for GKAP, a PSD-95 …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… (MAGUK) family scaffolding proteins, SAP102 and PSD-95, are involved in the switch from predominance of NMDA receptors rich in NR2B subunits to that of NMDA receptors rich in NR2A subunits. Normally, eye opening causes PSD-95 levels to increase at synapses and its interactions with NR2A to …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… AD mice. We reveal that Arc is associated with PSD-95/NMDAR and filamin A (FLNA) signaling pathways. Further, we identify protein kinase C (PKC) and Src in the PSD-95/NMDAR complexes as well as JAK2 and PAK1 in the FLNA signaling cascade as the kinases that phosphorylate Arc following activation …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… localization of postsynaptic-density (PSD) protein-95 (PSD-95); and 4) phosphorylation of p44/p42-mitogen-activated protein kinases (p44/p42-MAPK), which influences activity of molecules involved in 5 HT2CR trafficking. We found decreased 5 HT2CR protein expression in total homogenate …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… NMDA receptor subunits NR2A and NR2B, and PSD-95. We found that mRNA of Neuroligin-1 and NR2B was substantially reduced, with no changes to NR2A or PSD-95 expression. These results suggest that neuronal Nogo-A may act to maintain elements of the neocortical excitatory synapse during …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… also increased post-synaptic scaffolding protein PSD-95 and the phosphorylation of tyrosine 1472 of NR2B-- both of which are documented markers for synaptically-localized NMDAR complex. These findings agree well with a growing literature on the dichotomous role of synaptic and extra-synaptic NMDAR …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, such as spatial learning. Under physiological conditions, Rph3A is present in approximately 50% …
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Eye-opening and control of visual synapse development in the mouse superior colliculus
… (EO) induces the appearance of dendritic PSD-95 and LTP in the sSC within 2-4 hours.
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A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… and angiogenesis. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl terminus. The PDZ motif has been reported to regulate cellular signaling and functions. Here we investigated the potential role of the PDZ motif in CXCR2-mediated EPC motility and angiogenesis. We have …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
… particularly postsynaptic density protein-95 (PSD-95) a postsynaptic structural protein present in glutamate synapses linked to NMDAR function, a key receptor in the glutamate excitation of descending interneurons (dINs). <br/><br/>After the behavioural assessment, the tadpoles were fixed …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl termini, which might interact with potential PDZ scaffold/adaptor proteins. We have previously reported that CXCR2 PDZ motif-mediated protein interaction is an important regulator for neutrophil …
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