Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"PSC"”.
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to delineate the role of PGE2 on human pancreatic stellate cells (PSC) hyper …
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Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a progressive chronic cholestatic liver disease, affecting young males predominantly. It causes stricturing of the intrahepatic and extrahepatic bile ducts, often leading to biliary cirrhosis, with an increased risk of colorectal and hepato-biliary …
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Primary sclerosing cholangitis: from genetic risk to disease biology
… world lives with Primary Sclerosing Cholangitis (PSC), an immune-mediated, inflammatory disease of the bile ducts that is highly co-morbid with inflammatory bowel disease (IBD). PSC confers risk of serious disease sequelae including hepatobiliary malignancy and progression to end-stage liver …
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Determination of thermo-mechanical variables during plain strain compression testing
Plane strain compression (PSC) resting is a method used to simulate the deformation condition of industrial rolling, namely that of plane strain, and is used extensively to describe the influence of deformation variables, being strain, strain rate and temperature, on microstructural evolution. …
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Effects of low oxygen culture on pluripotent stem cell differentiation and teratoma formation
Pluripotent stem cells (PSC) hold promise for the study of embryonic development and the treatment of many diseases. Most pluripotent cell research is performed in incubators with a gas-phase oxygen partial pressure (p02) of 142 mmHg. However, embryonic cells in early development are exposed to a …
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IMPACT OF BIOPHYSICAL CUES ON THE FUNCTIONAL MATURITY OF PLURIPOTENT STEM CELL DERIVED ENDOTHELIAL CELLS INTO ARTERIAL AND VENOUS SUBTYPES
Pluripotent stem cell derived endothelial cells (PSC-EC) are an upcoming alternate source for cardio-vascular clinical applications. However, PSC-ECs are functionally heterogeneous and functionally immature compared to primary ECs. Hence, this study aims to functionally mature them to either …
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Psychological sense of community in Jewish adolescents of Perth, Western Australia
… paper explores Psychological Sense of Community (PSC) in the Jewish adolescent population of Perth. The main aim was to investigate the differences between student attending the private Jewish School (Carmel) or another school within the metropolitan area. Participants were recruited from Carmel …
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Connective Tissue Growth Factor in Pancreatitis
… deposition by pancreatic stellate cells (PSC). Improved understanding of the processes of inflammation and fibrosis are needed to identify the underlying mechanisms involved and to develop effective therapies, which are currently lacking. These studies reveal an important role for …
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The role of psychological sense of community in the life adjustment of 'coloured' South African immigrants
… how psychological sense of community (PSC) related to a group that had no choice in group membership. In the first stage of the study the PSC model was used to build a profile of a politically constructed group. The second stage of this project investigated the extent to which a PSC …
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Critical analysis of simulated thermomechanical processing of aluminium can body stock
Hot Plane Strain Compression (PSC) testing is a thermomechanical testing method used to simulate the deformation condition of industrial rolling. Thermomechanical processing (TMP) factors such as the amount of strain, strain rate and temperature all influence the microstructural evolution. The …
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Perceived Social Class, College Interest, and Post-Secondary Goals: An Application of the Scat Interest and Choice Model
… investigate the role of perceived social class (PSC) in the educational development of 176 racially and economically diverse high school students. PSC was defined based on the tenants of differential status identity theory (Fouad & Brown, 2000) and then incorporated as a person variable in the …
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What is the role of chaplaincy in the delivery of restorative justice in prisons in England and Wales? A case-study of HMP Birmingham
… RJ introduced some faith-based programmes to the PSC. In addition, it analyzes the relationship between restorative justice and religion. Secondly, it examines the PSC in three periods of time. Non-Christian faith representatives took their place the first time in the PSC in 1952. The exclusive …
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Pharmaceutical supply chain resilience. An exploratory analysis of vulnerabilities and resilience strategies in the face of dynamic disruptions in the UK pharmaceutical supply chain
… to explore why the Pharmaceutical Supply Chain (PSC) in the UK is susceptible to the impact of dynamic disruptions and examine how resilience strategies have were employed to reduce the effects of these disruptions. The Complex Adaptive System (CAS) theory was used as a framework in an …
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Primary sclerosing cholangitis
… patients with primary sclerosing cholangitis (PSC), 20 males median age 42 years, were studied in order to define prognostic variables and determine the influence of surgery on outcome. Presentation was usually with insidious cholestasis or recurrent cholangitis. Twenty six patients (72 per …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… how apigenin limits pancreatic stellate cell (PSC)-mediated fibrosis. Apigenin inhibited PSC proliferation, induced PSC death, reduced PSC transcription of extracellular matrix proteins collagen and fibronectin, proliferative cofactor PCNA, and cytokines TGF-β, IL-6, and IL-8. The last aim was …
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An analysis of the relationship between psychosocial safety climate and the work-school-interface for non-traditional students in South Africa
… et al., 2008). The psychosocial safety climate (PSC) is an emerging construct which refers to the shared perceptions regarding policies, practices and procedures designed to protect the psychological health of employees (Dollard et al., 2012). This study builds on existing research in the work - …
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Machine learning and data analytics for liver disease modeling
Primary sclerosing cholangitis (PSC) is a rare, progressive cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective …
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Der enterohepatische Kreislauf von T-Lymphozyten für die Entwicklung einer immunvermittelten Cholangitis bei chronisch entzündlichen Darmerkrankungen
Die Primäre sklerosierende Cholangitis (PSC) ist eine chronisch rezidivierende Entzündung der extra- und intrahepatischen Gallengänge bislang unbekannter Ursache, welche eng mit einer chronischen Kolitis assoziiert ist. Dabei weisen die in der Leber von PSC-Patienten vermehrt vorkommenden T-Zellen …
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Machine Learning Approaches to Improving the Transient Stability of Voltage-Source Converters in Weak Grids
… for developing power synchronization control (PSC) in weak power grids. First, the internal structure of the synchronization loop in PSC is modified to reduce vulnerability to grid transients by utilizing a back-calculation scheme. Also, the damping characteristics of PSC are enhanced to …
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The Distortionary Effect of Production Sharing Contract in Upstream Petroleum Industry
… the effects of Production Sharing Contract (PSC) is largely understudied. Moreover, economic studies typically oversimplify the physics of the field and consequently end up with models which do not necessarily fully reflect the reality. In this study, we build a dynamic optimisation model …
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