Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"PSA-NCAM"”.
-
Pharmacological evaluation of the inhibition of polysialyltransferases as a therapeutic strategy in cancer. Characterisation of models for evaluating polysialic acid as a potential therapeutic target and pharmacological assessment of novel polysialyltransferase inhibitors
… decoration of the neural cell adhesion molecule (PSANCAM). PSA-NCAM is selectively re-expressed in a number of tumours including neuroblastoma, where it is thought to modulate tumour dissemination. Expression is strongly associated with poor clinical prognosis and an aggressive tumour phenotype. …
-
Stress and Hippocampal Plasticity
… polysialic acid neural cell adhesion molecule (PSA-NCAM) expression and neuronal excitability. In addition, the learning and memory process is dissected using a contextual fear conditioning paradigm in order to identify the component that can affect hippocampal cell proliferation. The results …
-
The Manipulation Of Apical Dendritic Plasticity And The Consequences For The Effects of Chronic Stress
… were treated with endo N, an enzyme that cleaves PSA from NCAM for at least 30 days. PSA-NCAM is a cell adhesion molecule present during plasticity in development and also following chronic stress in the hippocampus. PSA-NCAM removal did not cause cell death on its own or following chronic stress …
-
Molecular characterization of three mental illness susceptibility genes
… on three candidate genes: NRG1, ST8SIA2 and NCAM1, each associated with psychotic mental illness, and determine how these genes could be functionally involved in disease susceptibility. Working with case-control cohorts, analysis of the target genes was undertaken at the DNA, RNA and protein …
-
Effects of environmental complexity on neurogenesis in the hippocampal dentate gyrus
… involved in neuron proliferation/survival, iii) PSA-NCAM (the polysialylated form of the neural cell adhesion molecule), a molecule associated with neuronal migration. Total granule cell number in the dentate gyrus was evaluated by stereological methods, in Nissl-stained sections. Results. …
-
Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… co-express markers of neuronal cell migration (PSA-NCAM), GABAergic interneuron marker (GABA+), and specific transcription factors (SCGN+SP8+) associated with the caudal- and lateral ganglionic eminence progenitor domains in the ventral forebrain. Moreover, I found that DCX+ neuroblasts are …
-
Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales
… neuronas TH+ periventriculares coexpresando PSA-NCAM. 17) La infusión de vehículo alcohólico sí indujo la reaparición de la señal nestina+ en áreas observadas en ratas prepúberes: núcleo arcuato, órgano subcomisural, receso colicular y pared acueductal. El alcohol podría tener un papel …