Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PS exposure"”.
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Understanding the mechanisms of phosphatidylserine exposure in sickle cells
… membrane permeability, high phosphatidylserine (PS) exposure, altered RBC rheology and fragility. The high PS exposure is considered to cause some of the hallmark complications of the disease such as vascular occlusion, anaemia and inflammation. This study investigates the possible physiological …
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Physiological and pharmacological factors affecting sickle cell function
… (HbS) polymerisation, phosphatidylserine (PS) exposure and significantly increased cation permeability via the KCl cotransporter (KCC), and are critical to the pathogenesis of SCD. The outcome of these abnormal features usually results in altered red blood cell (RBC) fragility and rheology, …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… the anionic phospholipid, phosphatidylserine (PS), in their outer leaflet enabling coagulation complex assembly on the negatively charged surface. Assembly of the tenase and prothrombinase complexes enhances their activity, increasing thrombin generation. PS is normally confined to the inner …
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Host cell-pathogen interactions between erythrocytes and P. falciparum: apoptotic mimicry?
… In this study, we focused on phosphatidylserine (PS) and its possible role in malaria pathogenesis through phagocytosis. Plasmodium falciparum was found to induce PS exposure in both infected and uninfected erythrocytes which could represent a form of apoptotic mimicry; therefore, aiding in …
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Functional Asymmetry of The Immune Cell Plasma Membrane
… is most prominent for phosphatidylserine (PS), a negatively charged lipid that is found almost exclusively on the cytoplasmic (inner) leaflet of the plasma membrane. This energetically unfavorable asymmetry is maintained by the activity of ATP-dependent transporters called flippases and …
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Phosphatidylserine-Based Nanoparticles For Tolerance Induction Towards Therapeutic Proteins
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in the cell membrane. Despite comprising 12% of total phospholipid and being restricted primarily in the inner leaflet of the membrane bilayer, the consequences of PS externalization to the outer leaflet is biologically …
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Inhibiting platelet scramblase activity
… platelets expose phosphatidylserine (PS) which acts as a surface for binding of the tenase (FIXa/VIIIa) and prothrombinase (FXa/Va) complexes that generate a burst of thrombin production responsible for occlusive clot formation. All current anti-platelet drugs are associated with …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… PGN635 to image the exposed phosphatidylserine (PS) on the tumor vascular endothelial cells and evaluate the enhanced exposure of PS as a result of radiation therapy in mice subcutaneous tumors. Both in vitro and in vivo studies verified the binding of SPIO-PGN635 and showed elevated PS exposure …