Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"PRRSV"”.
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Assessment of Tonsil-Oral-Scrubbing (TOSc) to detect PRRSV RNA in sows and application of TOSc for PRRSV dynamics in breeding herds
… reproductive and respiratory syndrome virus (PRRSV) continues to pose a significant threat to the global swine industry. One major problem for PRRSV control and elimination in the breeding herd is the persistence of PRRSV at herd level, increasing time to stability (Linhares et al., 2014; …
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Sialoadhesin is not required for infection of pigs with PRRSV-1
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)
… 560 million US dollars every year. Modified-live PRRSV vaccines (MLV) are the most effective option currently available for the control of the disease. MLVs can confer solid protection against homologous re-infection and have significant effects in reducing viral shedding. But the vaccine efficacy …
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Reverse Genetics-based Approaches to Attenuate Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
… reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically-important swine pathogen. As the emergences of novel virulent strains of PRRSV continue to occur worldwide, rapid vaccine development is the key for effective control of ongoing PRRSV outbreaks. With the …
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Effects of variation in N-linked glycosylation site on antibody mediated neutralization in PRRSV
… Reproductive and Respiratory Syndrome Virus (PRRSV) is a 15Kb enveloped positive-sense, single stranded RNA virus. More than two decades after the emergence of PRRSV, much is known about the viral genome, spread, and pathogenesis of the disease but our knowledge of the protective immune …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
… reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically devastating pathogen affecting the global swine industry. Since the emergence of the virus in the late 1980s, vaccination strategies aimed to control the virus have not been very effective. Current commercial …
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Surveillance in contemporary swine herds - the case of porcine reproductive and respiratory syndrome virus (PRRSV)
… reproductive and respiratory syndrome virus (PRRSV) infection. In particular, but not exclusively, the aim of this research was to evaluate the oral fluid emzyme-linked immunosorbent assay (ELISA) could be used to detect anti-PRRSV antibody isotypes. This problem was addressed in the logical …
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Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells
… reproductive and respiratory syndrome virus (PRRSV). The specific mechanisms of co-infection that lead to clinical disease are not fully understood, but immune modulation by the co-infecting viruses is thought to play a critical role. The ability of dendritic cells (DC) infected with PRRSV, …
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Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions
… reproductive and respiratory syndrome virus (PRRSV) is the cause of a pandemic that has been devastating the U.S. and global swine industry for more than twenty years. PRRSV vaccine development is challenging due to virus heterogeneity. Evidence indicates that the major envelope protein, GP5, …
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Cytokine modulations by type I interferon suppression-negative and NF-κB activation-negative Porcine Reproductive and Respiratory Syndrome Virus
… reproductive and respiratory syndrome virus (PRRSV) suppresses innate immunity, namely, type I interferons (IFNs-α/β) during infection and predisposes infected hosts to secondary bacterial infections. PRRSV also activates NF-κB signaling such that the secondary infection may trigger enhanced …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
… reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogenics affecting swine industry worldwide. PRRSV is a single-stranded and positive sense RNA virus that belongs to the family of the Arteriviridae (genus Arterivirus). PRRSV has a restricted host …
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Molecular characterization of the major envelope protein of porcine reproductive and respiratory syndrome virus (PRRSV) and evaluation of its use for a diagnostic assay, vaccine development, and the examination of quasispecies evolution
… we further analyzed the pathogenesis of PRRSV through genetic characterization, assay development, and quasispecies evaluation using the PRRSV ORF5 gene while also attempting to develop an improved PRRS vaccine. To explore the possible mechanism for the emergence of acute PRRS, the open …
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Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
… reproductive and respiratory syndrome virus (PRRSV) has emerged as the most economically important swine pathogen affecting pig industries worldwide. Vaccination is the principal means that have been used for prevention of PRRSV infection. However, the currently available vaccines for PRRSV …
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Elucidating the Role of Antigen-presenting Cells in the Immunopathogenesis of the Porcine Reproductive and Respiratory Syndrome Virus
… reproductive and respiratory syndrome virus (PRRSV) is a positive sense single-stranded RNA virus of the arteriviridae family and is one of the most economically devastating pathogens in the swine industry today. The PRRSV was discovered in the early 1990s in Europe and the United States, with …
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Intranasal Immunization of Pigs with Porcine Reproductive and Respiratory Syndrome Virus like Particles Plus 2’, 3’ –cGamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge
… reproductive and respiratory syndrome virus (PRRSV) is an economically devastating virus that causes a persistent infection and spreads quickly. The virus causes abortions in sows and respiratory diseases in young piglets. Current PRRSV vaccines appear to provide limited cross-protection. A …
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Novel approaches towards vaccine developments against porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus
… syndrome (PRRS) is caused by PRRS virus (PRRSV). Both PCV2 and PRRSV have caused devastating diseases in the swine industry worldwide, resulting in immense economic losses. One of the most common co-infections in the swine industry is PCV2 and PRRSV. The aim of this dissertation research …
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Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
… reproductive and respiratory syndrome virus (PRRSV) causes the economically most important viral disease in swine industry today. The virus is a major threat to swine health worldwide, since it is both associated with the porcine respiratory disease complex and the cause of severe reproductive …
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Development of a Fluorescence Microsphere Immunoassay for Detection of PRRSV Infection Using Oral Fluid Samples as an Alternative to Serum-based Assays
… reproductive and respiratory syndrome virus (PRRSV) continues to be one of the most devastating diseases in the swine industry throughout the world. PRRSV has caused the swine industry more than $600 million a year. PRRSV causes late term abortions, infertility, and severe respiratory disease …
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Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… responsible for this disease, PRRS virus (PRRSV), has developed the ability to subvert the immune response of its host. Evidence available at the outset of this project hinting that subversion of the immune system was a possibility, were the observations that PRRSV infection provoked a …
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The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… reproductive and respiratory syndrome virus (PRRSV) increases inflammatory cytokines in the offspring, influences myogenic gene expression, and decreases total muscle fiber number. Disease and inflammation during gestation influences DNA methylation. Methylation, consisting of a methyl group …
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