Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"PRRS"”.
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Analysis of Porcine Immunity in PRRS Virus
… porcine reproductive and respiratory syndrome (PRRS). This disease is caused by a recently emerged virus of swine (PRRSV) that has been classified in the Arteriviridae family. Members of this family are small, cytolytic, positive-stranded, enveloped RNA viruses. The goals of these studies were …
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The role of -2/-1 ribosome frameshifting mechanism in PRRS virus replication
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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CONPRRS-ATD : Aplicació de tractament de dades laboratorials front la malaltia del PRRS
CONPRRS és un projecte per al control de la malaltia del PRRS a nivell estatal que compta amb la participació d'experts en l'àmbit de la sanitat animal provinents de diferents universitats i centres de recerca de l'estat espanyol. CONPRRS-ATD és l'aplicació web que té com a objectiu la gestió de …
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Development of confirmatory testing strategies for suspect false PRRS-positive reactors in diagnostic serology
<p>The commercial ELISA kit (IDEXX HerdChecky PRRS) has been the main serodiagnostic tool for PRRS virus (PRRSV) in North America and many pig producing regions throughout the world. Although the kit has been mostly a reliable test for detecting PRRSV exposure at the herd level, the specificity of …
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The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection
… aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of …
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Impact of the implementation of the mcrebel management program in a commercial breed-to-wean unit following an infection with porcine reproductive and respiratory syndrome
… Porcine Reproductive and Respiratory Syndrome (PRRS) virus under commercial conditions. The study was carried out at a breed-to-wean facility that had recently tested positive for PRRS 1-7-4 wild type strain. The study used a randomized complete block design (blocking factor was farrowing date) …
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Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
… surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be tightly regulated. How PTI signalling is negatively regulated in plants …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit different responses are not very well …
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The Genetic Impact of Stress Responsiveness and Disease Susceptibility in Pigs
… porcine reproductive and respiratory syndrome (PRRS) virus. Total WBC, CORT, macrophage sub-populations, PHAGO, and performance measures were different in pigs infected with PRRS compared to non-infected pigs. Heat stress influenced CORT and performance measures of pigs. However, PRRS and heat …
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
Pattern Recognition Receptors (PRRs) are a group of evolutionarily conserved and germline-encoded cellular receptors of the innate immune system that are responsible for recognizing and responding to the entirety of the pathogens a host encounters. The ingenuity of the innate immune system is that …
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Molecular characterization of the major envelope protein of porcine reproductive and respiratory syndrome virus (PRRSV) and evaluation of its use for a diagnostic assay, vaccine development, and the examination of quasispecies evolution
Porcine reproductive and respiratory syndrome (PRRS) is a viral disease that has devastated the global swine industry since the mid 1980s. Although modified live vaccines (MLVs) are typically used for the prevention of clinical disease, they are not always fully effective. Additionally, acute PRRS …
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Characterisation of potential regulators of PAMP-triggered immunity
… surface-localised pattern-recognition receptors (PRRs). EFR and FLS2 are well characterised PRRs, which recognise the bacterial elongation factor Tu and flagellin, respectively. A variety of downstream responses upon PAMP perception have been described. However, it is still poorly understood how …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… families of pattern recognition receptors (PRRs), their roles in the innate immune system and how they are regulated by the invading pathogens have been the subjects of extensive research. Cellular helicases RIG-I and MDA5, and Toll-like receptor 3 (TLR3) are PRRs that detect virus-specific …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… to pattern-recognition receptors family (PRRs). Among PRRs, RIG-I-like receptors (RLRs), including RIG-I, MDA5 and LGP2, are responsible for sensing intracellular viral RNAs. MAVS, a mitochondria-localized transmembrane protein, transduces signaling from RIG-I and MDA5 to activate …
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Virus-like particles as a vaccine against porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome (PRRS) is the most significant infectious disease currently affecting the swine industry worldwide. Several inactivated and modified live vaccines (MLV) have been developed to curb PRRSV infections. The unsatisfactory efficacy and safety of these …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… viruses by pathogen recognition receptors (PRRs) first illicits an innate immune response which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the adaptors TRIF …
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Length Of Playing Time and Previous History of Injury as Predictors of Readiness to Return to Play
… Readiness to Return to Play (I-PRRS) scale, which measures how psychologically ready an injured athlete is to return to sport participation; however the measure has never been measured for potential influence of time spent in the rehabilitation process. Therefore, the purpose of …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… MDA5, cytosolic pattern recognition receptors (PRRs) of the RIG-I-like receptor (RLR) protein family that recognize viral RNA and activate defense programs that suppress infection. We evaluated the individual functions of RIG-I and MDA5 both in vitro and in vivo in pathogen recognition and …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… the action of pattern recognition receptors (PRRs) the vertebrate immune system is able to detect and respond to invading pathogens. PRRs bind conserved microbial components and subsequently initiate pro-inflammatory defense programs. While effective at eliminating pathogens, these …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… signals called pattern recognition receptors (PRRs). These PRRs trigger the production of type-I interferon (IFN-I), which is essential to establish antiviral innate immunity, allowing for the clearance of the offending organism. This process is tightly controlled by post-translational …
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