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Showing 1 to 20 of 129 for “"PRP"”.
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Modelling prion-induced neurodegeneration in PrP transgenic Drosophila
… aim of my thesis was to develop and characterise PrP transgenic Drosophila melanogaster of various genotypes to study the process of prion-induced neurodegeneration in this model. Prion diseases are caused by the occurrence of an abnormally-folded form of PrP (PrPSc) protein that arises either …
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Aggregation & Localization of a Disease-Associated Prion Protein (PrP) Mutant
… of a Disease-Associated Prion Protein: PrP) Mutant by Andrea Rhonda Zaragoza Medrano Doctor of Philosophy in Biology and Biomedical Sciences: Genetics) Washington University in St. Louis, 2009 Professor David A. Harris, Chairperson Prion protein: PrP) is a GPI-anchored sialoglycoprotein …
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Κολπική ενδυνάμωση (PRP): μια εναλλακτική προσέγγιση για την αντιμετώπιση της κολπίτιδας
Εισαγωγή Το πλούσιο σε αιμοπετάλια πλάσμα (PRP) μπορεί να θεωρηθεί ως ένα ειδικό παρασκεύασμα πλάσματος στο οποίο η συγκέντρωση των αιμοπεταλίων είναι εξαιρετικά υψηλή. Το PRP έχει μελετηθεί διεξοδικά για πολλά χρόνια με μεγάλη επιτυχία σε διάφορους τομείς όπου έχει εφαρμοστεί, φέρνοντας δραματικά …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… cell (DC) interaction with infectious prions (PrPSc) represents an important part of prion pathogenesis. Previous studies have shown that DCs are likely among the first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC activation by …
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Deciphering the Molecular Basis of the Species Barrier in Prion Disease Using Bank Vole PrP
… predominantly α-helical cellular protein called PrPC into a β-sheet rich conformer referred to as scrapie or PrPSc. The infectious nature of this conformer enables it to template the conversion of PrPC into additional copies of PrPSc, the efficiency of which depends on the sequence-encoded …
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Etablierung eines Modellsystems zur zellulären und biochemischen Phänotypisierung von Prionproteinen unter Verwendung von GFP-PrP-Chimären
… Transport bzw. die zelluläre Lokalisation dieser PrPMutanten bekannt. Aus diesem Grund wurde erstmalig ein Modellsystem mit homologen Maus-PrPs in der vielfach eingesetzten Maus-Neuroblastom-Zelllinie N2a etabliert, welches durch die Verwendung des grünen Fluoreszenzproteins (GFP) als integrales …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of clearly distinguishing input PrP-res from either PrP-res or …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of clearly distinguishing input PrP-res from either PrP-res or …
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Prion protein in health and disease
The prion protein (PrP) is a conserved glycoprotein tethered to cell membranes by a glycosylphosphatidylinositol anchor. In mammals, PrP is expressed in many tissues, most abundantly in brain, heart, and muscle. Importantly, PrP is required for prion diseases, which are neurodegenerative diseases …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
Prion protein (PrP) is expressed on a wide variety of cells and plays an important role in the pathogenesis of transmissible spongiform encephalopathies. However, its normal function remains unclear. Mice that do not express PrP exhibit deficits in spatial memory and abnormalities in excitatory …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
Prion protein (PrP) is expressed on a wide variety of cells and plays an important role in the pathogenesis of transmissible spongiform encephalopathies. However, its normal function remains unclear. Mice that do not express PrP exhibit deficits in spatial memory and abnormalities in excitatory …
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Vergleichende Analyse der Gerstmann-Straeussler-Scheinker-Syndrom-assoziierten Mutation A117V mit der neuen pathogenen Mutation G114V des humanen Prion-Proteins in vivo und in vitro
… its fully translocated form, the prion protein (PrP) can exist in two transmembrane forms (NtmPrP and CtmPrP), which span the lipid bilayer in either direction. Certain mutations in the membrane-spanning segment of PrP have been shown to increase synthesis of CtmPrP and result in …
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Molecular Basis of Mammalian Prion Protein Misfolding
… In mammals, the only known prion protein is PrP. The misfolding of PrP is a key event underlying Transmissible Spongiform Encephalopaties (TSEs), fatal neurological disorders that affect many mammalian species. A self-propagating abnormally folded PrP is believed to be the essential component …
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
… class of infectious agents in which a protein, PrPSc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies (TSEs), which affect both, humans and animals. Human prion diseases occur in infectious, sporadic …
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Exploring the relationship between performance-related pay and risk behaviours: the role of emotion and contextual evaluation in a case study of financial traders
… relationship between performance-related pay (PRP) and risk behaviours. Despite the conspicuous debate on this topic, we still do not fully understand how, when and why PRP influences risk behaviours. Extant PRP literature has produced mixed and inconclusive findings, primarily because it …
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Interaction studies of the cellular prion protein
… humans and mammals caused by the prion protein (PrP) which is well conserved among the species. In this thesis the biochemical properties and the function of prion protein were investiagted using different methods. The oligomerisation state of the prion protein analysed by size exclusion …
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Mechanistic and Clinical Studies of Platelet Rich Plasma: A Simple Clinical Method for Enhancing Bone and Soft Tissue Healing
Platelet rich plasma (PRP) is a methodology of using a patient's own platelets to enhance bone and soft tissue healing following oral surgical procedures. Whole blood is drawn from the patient by conventional phlebotomy techniques and then centrifuged with the formation of a distinct middle layer …
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Single Molecule Fluorescence Studies of Prions and Prion-like Proteins
… states that the misfolded form of prion protein (PrP) is the sole constituent of prions, and the self-propagating process of PrP is considered to play a central role in prion pathogenesis. Prions are believed to propagate when a PrP assembly enters a cell and replicates to produce two or more …
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Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo
… nach fokaler zerebraler Ischämie in PrP überexpremierenden Mäusen (TG35). Weiterhin soll der Einfluss der PrP-Überexpression auf die ischämische Regulation der zelltodrelevanten PI3-Kinase/Akt und MAPK/Erk-Signalkaskaden untersucht werden. In den durchgeführten Experimenten zeigten …
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Identification of gene expression changes in Drosophila models of mammalian prion diseases
… associated with mutations in the prion protein (PrP) gene, such as genetic CJD (gCJD) and fatal familial insomnia. Prion diseases are caused by the misfolding of the cellular isoform of PrP (PrPC) into the disease-associated isoform (PrPSc). Prion inoculated wild-type and PrP transgenic mice have …
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