Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PRMT6"”.
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… Mouse Models to Investigate Biological Roles of PRMT6</strong></p> <p>Alessandra Di Lorenzo, Ph.D. Candidate</p> <p>Mentor: Dr. Mark T. Bedford</p> <p>Protein Arginine Methyltransferase 6 (PRMT6) is the histone tail writer that methylates the H3R2 (arginine 2 of histone H3) residue, which …
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The Regulation of Dna Methylation In Mammalian Development and Cancer
… In a separate project, I demonstrate that PRMT6, an arginine methyltransferase responsible for asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a), negatively regulates maintenance DNA methylation by impairing the recruitment of the Dnmt1-Uhrf1 complex to chromatin, thereby …
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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… I show that methyltransferases CARM1 and PRMT6 methylate this residue in vitro and in vivo. Using chemically-defined "designer" histones I also show that methylation of H3R42 stimulates transcription in vitro from chromatinized templates. Using peptide pull down experiments combined with …