Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PRMT"”.
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… of Type-I protein arginine methyltransferases (PRMTs) with MS023 re-sensitizes A2780R cells to carboplatin, reducing IC50 by up to 56%, and abrogates the enhanced mitochondrial activity. MS023 treatment induces depolarization of the mitochondrial membrane, diminishes mitochondrial volume and …
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… of nine protein arginine methyltransferases or PRMTs. These enzymes deposit one or two methyl groups to the nitrogen atoms of arginine side-chains. Elucidating the substrate specificity of each PRMT will promote a better understanding of which signaling networks these enzymes contribute to. …
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Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
… lines, combination therapy with EZH2 and Type I PRMT inhibitors showed synergy. Interestingly, Type I PRMT inhibitors were also highly effective as a single-agent, and mediated apoptosis in lymphoma cells by transcriptionally down-regulating the anti-apoptotic protein BCL2. To summarize, we have …
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
<p>Protein arginine methyltransferases (PRMTs) are SAM-dependent enzymes that catalyze the mono- and di-methylation of peptidyl arginine residues. Although all PRMTs produce mono-methyl arginine (MMA), type I PRMTs go on to form asymmetrically dimethylated arginine (ADMA), while type II enzymes …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The majority of Type I enzymes asymmetrically dimethylate Glycine- and Arginine-rich (GAR) motifs, except for PRMT4, which methylates Proline-, Glycine-, and Methionine-rich (PGM) motifs. The same …
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The Design, Synthesis and in vitro Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Degradation of Protein Arginine Methyltransferase 1
Protein arginine methyltransferase 1 (PRMT1) is a protein responsible for the asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and the reduction of PRMT1 activity reduces cell proliferation and tumour growth in cell and animal models of cancer. A reduction in …