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Showing 1 to 1 of 1 for “"PRK1/PKN1"”.
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… of the HR1a domain from the RhoA effector, PRK1/PKN1 kinase, as a starting point for peptide inhibitor design. HR1a binds to RhoA with nanomolar affinity and forms an anti-parallel coiled coil. This dissertation starts with mutagenesis studies on the RhoA-binding residues of HR1a to identify …