Global ETD Search
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Showing 1 to 4 of 4 for “"PRK1"”.
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Functional analysis of syp1, a novel substrate of the serine/threonine kinase prk1
… actin cytoskeleton. Syp1p is a new substrate of Prk1p, a kinase that regulates actin dynamics. Syp1p colocalizes with actin cytoskeleton whose integrity is required for the polarized localization of Syp1p. Syp1p can physically interact with the actin-associated protein Sla1p. Furthermore, Syp1p …
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Structural and Biochemical Characterisation of the HR1 domains of the Protein Kinase C-related kinase family
… kinases consists of three members, PRK1, PRK2 and PRK3, all of which are Rho family effectors. PRKs have three N-terminal Homology Region 1 (HR1) domains, HR1a, HR1b and HR1c. These are predicted antiparallel coiled coils which interact with the Rho proteins. While HR1a and HR1b …
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VPS1 on Dynamics of Endocytic Components and Endocytic Scission
… might attribute to the decreased efficiency of Prk1 kinase and Sjl2 phosphatase, as well as the fragmented actin cables. In addition, I observed that both the full-length of VPS1 and the C-terminal half of the gene lacking the GED domain interact genetically at a non-permissive temperature with …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… of the HR1a domain from the RhoA effector, PRK1/PKN1 kinase, as a starting point for peptide inhibitor design. HR1a binds to RhoA with nanomolar affinity and forms an anti-parallel coiled coil. This dissertation starts with mutagenesis studies on the RhoA-binding residues of HR1a to identify …